Regulatory mechanisms of one-carbon metabolism enzymes.
Regulatory mechanisms of one-carbon metabolism enzymes.
复制标题
单碳代谢酶的调控机制。
DOI：
10.1016/j.jbc.2023.105457
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发表时间：
2023-12
影响因子：
4.8
通讯作者：
Kanarek, Naama
中科院分区：
文献类型：
--
作者：
Petrova, Boryana;Maynard, Adam G.;Wang, Peng;Kanarek, Naama
一碳代谢是几种氨基酸、甲基供体和核苷酸生物合成的关键代谢途径。该途径主要依赖于碳单元从氨基酸丝氨酸通过辅因子叶酸（以其几种形式）转移到最终的碳受体，包括用于蛋白质，RNA和DNA甲基化的核苷酸和甲基。通过核糖体RNA，核苷酸是DNA复制、DNA修复、基因表达和蛋白质翻译所必需的。因此，一碳代谢途径对所有细胞的细胞生长和功能都是必不可少的，但对快速增殖的细胞特别重要。一碳代谢的调节是该途径的正常和病理功能的关键方面，例如在癌症中，劫持这些调节机制会增加对核苷酸的需求。一碳代谢在几个水平上受到调节：通过基因表达、翻译后修饰、亚细胞区室化、变构抑制和反馈调节。本文综述了单碳代谢的相关调控机制，并提出了进一步研究的必要性。该综述旨在整合癌症代谢的两个主要方面-营养传感和一碳代谢的下游信号传导，因为虽然其中每一个都对癌细胞的增殖至关重要，但它们的整合对于全面了解转化细胞中的细胞代谢至关重要，并且可以导致临床相关的见解。
One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the transfer of a carbon unit from the amino acid serine, through the cofactor folate (in its several forms), and to the ultimate carbon acceptors that include nucleotides and methyl groups used for methylation of proteins, RNA, and DNA. Nucleotides are required for DNA replication, DNA repair, gene expression, and protein translation, through ribosomal RNA. Therefore, the one-carbon metabolism pathway is essential for cell growth and function in all cells, but is specifically important for rapidly proliferating cells. The regulation of one-carbon metabolism is a critical aspect of the normal and pathological function of the pathway, such as in cancer, where hijacking these regulatory mechanisms feeds an increased need for nucleotides. One-carbon metabolism is regulated at several levels: via gene expression, posttranslational modification, subcellular compartmentalization, allosteric inhibition, and feedback regulation. In this review, we aim to inform the readers of relevant one-carbon metabolism regulation mechanisms and to bring forward the need to further study this aspect of one-carbon metabolism. The review aims to integrate two major aspects of cancer metabolism—signaling downstream of nutrient sensing and one-carbon metabolism, because while each of these is critical for the proliferation of cancerous cells, their integration is critical for comprehensive understating of cellular metabolism in transformed cells and can lead to clinically relevant insights.
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DOI：
10.1016/j.tem.2015.09.012
发表时间：
2015-12
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Castello A;Hentze MW;Preiss T
通讯作者：
Preiss T
DOI：
10.1126/science.aaz2193
发表时间：
2020-07-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chi Y;Remsik J;Kiseliovas V;Derderian C;Sener U;Alghader M;Saadeh F;Nikishina K;Bale T;Iacobuzio-Donahue C;Thomas T;Pe'er D;Mazutis L;Boire A
通讯作者：
Boire A
DOI：
10.1016/j.bbamcr.2013.02.028
发表时间：
2014-01
影响因子：
5.1
作者：
Bassermann, Florian;Eichner, Ruth;Pagano, Michele
通讯作者：
Pagano, Michele
影响因子：
64.8
作者：
BERTINO, JR;HUENNEKENS, FM;GABRIO, BW
通讯作者：
GABRIO, BW
DOI：
10.1073/pnas.94.7.3290
发表时间：
1997-04-01
影响因子：
11.1
作者：
Blount, BC;Mack, MM;Ames, BN
通讯作者：
Ames, BN