Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury.

Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury.
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DOI:
10.3969/j.issn.1673-5374.2012.14.010
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发表时间:
2012-05-15
影响因子:
6.1
通讯作者:
Yang X
Yang X
中科院分区:
医学2区
文献类型:
--
作者:
Li L;Yang M;Wang C;Zhao Q;Liu J;Zhan C;Liu Z;Li X;Wang W;Yang X

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We investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the curative effects of mesenchymal stem cells. This study reviewed the effects of tumor necrosis factor-α, vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, basic fibroblast growth factor, insulin like growth factor-1, stromal cell-derived factor and monocyte chemoattractant protein-1, 3 during mesenchymal stem cell migration to damaged sites, and analyzed the signal transduction pathways involved in their effects on mesenchymal stem cell migration. The results confirmed that phosphatidylinositol 3-kinase/serine/threonine protein kinases and nuclear factor-κB play crucial roles in the migration of mesenchymal stem cells induced by cytokines and chemokines.
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