Comparison of 68Ga-DOTANOC and 18F-FDG PET-CT Scans in the Evaluation of Primary Tumors and Lymph Node Metastasis in Patients With Rectal Neuroendocrine Tumors.
Comparison of 68Ga-DOTANOC and 18F-FDG PET-CT Scans in the Evaluation of Primary Tumors and Lymph Node Metastasis in Patients With Rectal Neuroendocrine Tumors.
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68Ga-DOTANOC 和 18F-FDG PET-CT 扫描评估直肠神经内分泌肿瘤患者原发肿瘤和淋巴结转移的比较。
DOI：
10.3389/fendo.2021.727327
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发表时间：
2021
影响因子：
5.2
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Zhou Z;Wang Z;Zhang B;Wu Y;Li G;Wang Z
直肠神经内分泌肿瘤（RNETs）淋巴结转移预示预后不良。然而，淋巴结转移的评估仍然是一个挑战。有报道称，68Ga-DOTANOC和18F-FDG PET-CT扫描可用于直肠神经内分泌肿瘤（RNETs）的检查。本研究旨在评估两种示踪剂在RNETs中识别原发肿瘤和淋巴结转移的能力。2014年1月至2021年1月，共有537例RNETs患者入组。68Ga-DOTANOC和18F-FDG PET-CT扫描用于评估原发肿瘤和LN组转移。PET图像通过视觉和半定量评价进行评价。采用受试者工作特征（ROC）曲线分析，探讨68Ga-DOTANOC和18F-FDG PET的SUVmax在预测LN组转移中的作用。52例术前行18F-FDG PET-CT扫描的68Ga-DOTANOC患者行内镜下原发肿瘤活检或清扫术，11例行直肠手术并局部淋巴结清扫术。对于原发肿瘤，68Ga-DOTANOC通过目测的敏感性为89.58%，阳性预测值（PPV）为95.56%，而18F-FDG PET-CT的敏感性为77.08%，PPV为97.37%。对于预测LN组转移，68Ga-DOTANOC PET-CT的灵敏度为77.78%，特异性为91.67%，而18F-FDG PET-CT的灵敏度为38.89%，特异性为100%。68Ga-DOTANOC PET/CT的ROC曲线下面积（AUC）为0.852 (95%CI:0.723 ~ 0.981)，最佳SUVmax临界值为2.25；18F-FDG PET的AUC为0.664 (95%CI:0.415 ~ 0.799)，最佳SUVmax临界值为1.05。本研究表明，68Ga-DOTANOC PET-CT在视觉评估和半定量评估方面具有较高的敏感性和特异性，优于18F-FDG PET-CT，是一种很有前景的检测RNETs淋巴结转移的工具。
Lymph node metastasis of rectal neuroendocrine tumors (RNETs) predicts poor prognosis. However, the assessment of lymph node metastasis remains a challenge. It has been reported that 68Ga-DOTANOC and 18F-FDG PET-CT scans could be employed in the work-up of rectal neuroendocrine tumors (RNETs). This study aimed to assess both tracers’ ability to identify primary tumors and lymph node (LN) metastasis in RNETs. A total of 537 patients with RNETs were enrolled from January 2014 to January 2021. Both 68Ga-DOTANOC and 18F-FDG PET-CT scans were used to evaluate primary tumors and LN group metastasis. PET images were evaluated through visual and semiquantitative assessment. Receiver Operating Characteristics (ROC) curve analysis was used to investigate the performance of SUVmax of 68Ga-DOTANOC and 18F-FDG PET in predicting LN group metastasis. Fifty-two patients with preoperative 68Ga-DOTANOC with 18F-FDG PET-CT scans underwent endoscopic biopsy or dissection of the primary tumor, while 11 patients underwent rectal surgery together with regional LN dissection. For primary tumors, 68Ga-DOTANOC had a sensitivity of 89.58% and a positive predictive value (PPV) of 95.56% through visual assessment, while 18F-FDG PET-CT showed 77.08% sensitivity and 97.37% PPV. For the prediction of LN group metastasis, 68Ga-DOTANOC PET-CT had 77.78% sensitivity and 91.67% specificity, while 18F-FDG PET-CT had 38.89% sensitivity and 100% specificity according to visual assessment. The area under the ROC curves (AUC) for 68Ga-DOTANOC PET/CT was 0.852 (95%CI:0.723-0.981) with an optimal SUVmax cut-off value of 2.25, while the AUC for 18F-FDG PET were 0.664 (95%CI:0.415-0.799) with an optimal SUVmax cut-off value of 1.05. This study showed that 68Ga-DOTANOC PET-CT was a promising tool for detecting LN metastasis in RNETs with high sensitivity and specificity in visual assessment and semiquantitative assessment, which was better than 18F-FDG PET-CT.
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影响因子：
5.2
作者：
Alevroudis E;Spei ME;Chatziioannou SN;Tsoli M;Wallin G;Kaltsas G;Daskalakis K
通讯作者：
Daskalakis K
影响因子：
9.3
作者：
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通讯作者：
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影响因子：
6.2
作者：
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影响因子：
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作者：
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通讯作者：
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6.2
作者：
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通讯作者：
Modlin, Irvin M.