Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork.
Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork.
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DOI：
10.1371/journal.pone.0037150
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Oster H
中科院分区：
文献类型：
--
作者：
Barclay JL;Husse J;Bode B;Naujokat N;Meyer-Kovac J;Schmid SM;Lehnert H;Oster H
Shiftwork is associated with adverse metabolic pathophysiology, and the rising incidence of shiftwork in modern societies is thought to contribute to the worldwide increase in obesity and metabolic syndrome. The underlying mechanisms are largely unknown, but may involve direct physiological effects of nocturnal light exposure, or indirect consequences of perturbed endogenous circadian clocks. This study employs a two-week paradigm in mice to model the early molecular and physiological effects of shiftwork. Two weeks of timed sleep restriction has moderate effects on diurnal activity patterns, feeding behavior, and clock gene regulation in the circadian pacemaker of the suprachiasmatic nucleus. In contrast, microarray analyses reveal global disruption of diurnal liver transcriptome rhythms, enriched for pathways involved in glucose and lipid metabolism and correlating with first indications of altered metabolism. Although altered food timing itself is not sufficient to provoke these effects, stabilizing peripheral clocks by timed food access can restore molecular rhythms and metabolic function under sleep restriction conditions. This study suggests that peripheral circadian desynchrony marks an early event in the metabolic disruption associated with chronic shiftwork. Thus, strengthening the peripheral circadian system by minimizing food intake during night shifts may counteract the adverse physiological consequences frequently observed in human shift workers.
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DOI：
10.1073/pnas.011404098
发表时间：
2001-01-02
影响因子：
11.1
作者：
Li, C;Wong, WH
通讯作者：
Wong, WH
护士的转移工作：表型和基因型对适应的贡献。
影响因子：
3.7
作者：
Gamble KL;Motsinger-Reif AA;Hida A;Borsetti HM;Servick SV;Ciarleglio CM;Robbins S;Hicks J;Carver K;Hamilton N;Wells N;Summar ML;McMahon DG;Johnson CH
通讯作者：
Johnson CH
影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
2.8
作者：
Folkard, Simon
通讯作者：
Folkard, Simon
影响因子：
4.8
作者：
Ando, Hitoshi;Kumazaki, Masafumi;Fujimura, Akio
通讯作者：
Fujimura, Akio