Predictors of mortality rate among adult HIV-positive patients on antiretroviral therapy in Metema Hospital, Northwest Ethiopia: a retrospective follow-up study.
Predictors of mortality rate among adult HIV-positive patients on antiretroviral therapy in Metema Hospital, Northwest Ethiopia: a retrospective follow-up study.
复制标题
DOI：
10.1186/s12981-021-00353-z
复制
发表时间：
2021-05-05
影响因子：
2.2
通讯作者：
Angaw DA
中科院分区：
文献类型：
--
作者：
Workie KL;Birhan TY;Angaw DA
全球人类免疫缺陷病毒/获得性免疫缺陷综合症（艾滋病毒/艾滋病）是一个持续存在的公共卫生问题，发病率和死亡率很高。人们已努力通过提供抗逆转录病毒治疗来降低艾滋病毒/艾滋病相关的发病率和死亡率。然而，没有对像梅特马这样的边境地区的死亡率的发生率和预测因素进行调查。本研究旨在评估 Metema 医院接受抗逆转录病毒治疗的成年 HIV 阳性患者死亡率的预测因素。对2013年1月1日至2018年12月30日的ART患者进行回顾性随访研究。数据输入Epi-data 3.1并导出到STATA 14进行分析。 Kaplan-Meier 和 Log-Rank 检验用于比较不同变量类别之间的生存差异。在双变量分析中，将 p 值 < 0.20 输入到多变量分析中。多变量威布尔模型用于测量死亡风险并确定死亡的重要预测因素。 p值≤0.05时具有统计显着性的变量被认为是死亡率的预测因子。共有 542 名研究参与者参与。总体发病率为每 100 人年观察 6.7 例死亡（95% CI：5.4-8.4）。男性（HR = 2.4；95% CI：1.24–4.62），IV 期（HR = 5.64；95% CI：2.53–12.56），III 期（HR = 3.31；95% CI：1.35–8.10），结核病合并感染（HR = 3.71；95% CI：1.59–8.64）、低血红蛋白（HR = 4.14；95% CI：2.18–7.86）、BMI ≤ 15.4 kg/m2（HR = 2.45；95% CI：1.17–5.10）病毒载量 > 1000拷贝/ml（HR = 6.70；95% CI：3.4–13.22）被发现是接受ART治疗的HIV患者死亡率的重要预测因子。死亡发生率很高。作为男性，病毒载量、晚期阶段（III 和 IV）、结核病合并感染、低 BMI 和低血红蛋白的患者死亡风险较高。应特别关注男性患者，并需要对接受 ART 的艾滋病毒患者进行大量公共干预，以降低死亡率。在线版本包含可在 10.1186/s12981-021-00353-z 获取的补充材料。
Globally Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is an ongoing public health issue associated with high morbidity and mortality. Efforts have been made to reduce HIV/AIDS-related morbidity and mortality by delivering antiretroviral therapy. However, the incidence and predictors of mortality in border areas like Metema were not investigated. This study aimed to assess predictors of mortality rate among adult HIV-positive patients on antiretroviral therapy at Metema Hospital. Retrospective follow-up study was employed among ART patients from January 1, 2013, to December 30, 2018. Data were entered in Epi-data 3.1 and exported to STATA 14 for analysis. Kaplan–Meier and Log-Rank test was used to compare survival differences among categories of different variables. In bi-variable analysis p-values < 0.20 were entered into a multivariable analysis. Multivariate Weibull model was used to measure the risk of death and identify the significant predictors of death. Variables that were statistically significant at p-value < 0.05 were concluded as predictors of mortality. A total of 542 study participants were included. The overall incidence rate was 6.7 (95% CI: 5.4–8.4) deaths per 100 person-years of observation. Being male (HR = 2.4; 95% CI: 1.24–4.62), STAGE IV (HR = 5.64; 95% CI: 2.53–12.56), stage III (HR = 3.31; 95% CI: 1.35–8.10), TB-coinfection (HR = 3.71; 95% CI: 1.59–8.64), low hemoglobin (HR = 4.14; 95% CI: 2.18–7.86), BMI ≤ 15.4 kg/m2 (HR = 2.45; 95% CI: 1.17–5.10) and viral load > 1000 copy/ml (HR = 6.70; 95% CI: 3.4–13.22) were found to be a significant predictor for mortality among HIV patients on ART treatment. The incidence of death was high. Being male, viral load, those with advanced STAGE (III & IV), TB co-infected, low BMI, and low hemoglobin were at a higher risk of mortality. Special attention should be given to male patients and high public interventions needed among HIV patients on ART to reduce the mortality rate. The online version contains supplementary material available at 10.1186/s12981-021-00353-z.
登录
查看更多内容
影响因子：
3.7
作者：
Gupta A;Nadkarni G;Yang WT;Chandrasekhar A;Gupte N;Bisson GP;Hosseinipour M;Gummadi N
通讯作者：
Gummadi N
影响因子：
4.5
作者：
Boutayeb, Abdesslam
通讯作者：
Boutayeb, Abdesslam
影响因子：
3.8
作者：
Etard, JF;Ndiaye, I;Delaporte, E
通讯作者：
Delaporte, E
DOI：
10.1155/2014/250913
发表时间：
2014-01-01
期刊：
International scholarly research notices
影响因子：
--
作者：
Mengesha, Shibre;Belayihun, Bekele;Kumie, Abera
通讯作者：
Kumie, Abera
影响因子：
3.7
作者：
Johannessen A;Naman E;Ngowi BJ;Sandvik L;Matee MI;Aglen HE;Gundersen SG;Bruun JN
通讯作者：
Bruun JN