High ocular CMV copies and mismatched receipts may predict poor visual prognosis in CMV retinitis patients following allogeneic haematopoietic stem cell transplantation.
High ocular CMV copies and mismatched receipts may predict poor visual prognosis in CMV retinitis patients following allogeneic haematopoietic stem cell transplantation.
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DOI：
10.1186/s12886-017-0622-0
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发表时间：
2017-11-29
影响因子：
2
通讯作者：
Mo W
中科院分区：
文献类型：
--
作者：
Zhang Y;Ruan X;Yang W;Li L;Xian Z;Feng Q;Mo W
总结异基因造血干细胞移植（HSCT）后巨细胞病毒性视网膜炎患者的临床特征和影响视力结果的潜在因素。这项回顾性研究纳入了 2013 年 1 月至 2014 年 12 月期间在中国广州市第一人民医院接受造血干细胞移植后出现巨细胞病毒性视网膜炎的 12 名患者（19 只眼）。通过查阅血液科和眼科的医疗记录来评估人口统计学和临床特征、眼部表现和视力结果。所有患者在停止抗病毒治疗后至少进行 6 个月的随访。视觉结果被定义为改善、稳定和恶化。受试者由 7 名人类白细胞抗原匹配的收据和 5 名不匹配的收据组成。所有患者均接受全身和玻璃体内联合抗病毒治疗。 11 只眼睛的视力得到改善或稳定，而 8 只眼睛的视力下降。玻璃体巨细胞病毒载量低于1××104拷贝/ml的眼在视力预后良好的眼中所占比例高于巨细胞病毒拷贝数高于1××104拷贝/ml的眼（52.63% vs 5.26%，P<0.001）。人类白细胞抗原匹配的收据比不匹配的收据获得更好的视觉预后（47.37％vs10.53％，P<0.05）。病毒类型、血液中巨细胞病毒峰值、累及视网膜区域和大小对视力结果没有影响（均P>0.05）。高眼部巨细胞病毒拷贝和不匹配的收据可能是影响同种异体 HSCT 后巨细胞病毒视网膜炎患者视力结果的潜在不利因素。
To summarize the clinical characteristics and potential factors affecting the visual outcomes in patients with cytomegalovirus retinitis following allogeneic haematopoietic stem cell transplantation (HSCT). This retrospective study enrolled 12 patients (19 eyes) with cytomegalovirus retinitis after HSCT at Guangzhou First People’s Hospital in China between January 2013 and December 2014. Demographic and clinical characteristics, ocular manifestations and visual outcomes were evaluated by reviewing medical records at the Departments of Hematology and Ophthalmology. All patients were followed up at least 6 months after stopping antiviral therapy. The visual outcome was defined as improvement, stabilization and deterioration. The subjects were composed of 7 human leucocyte antigen-matched and 5 mismatched receipts. All patients received combined systemic and intravitreous antiviral therapy. Eleven eyes gained improved or stabilized visual acuity, while 8 eyes suffered deterioration. Eyes with cytomegalovirus load less than 1 × 104 copies/ml in vitreous accounted for higher rate in eyes with good visual prognosis than those with cytomegalovirus copies above 1 × 104 copies/ml (52.63% vs 5.26%, P < 0.001). Human leucocyte antigen-matched receipts gained better visual prognosis than those mismatched ones (47.37% vs10.53%, P < 0.05). The virus types, cytomegalovirus peak in the blood, involved retinal zone and size had no influence on the visual outcomes (all P > 0.05). High ocular cytomegalovirus copies and mismatched receipts may be potential adverse factors affecting visual outcomes in cytomegalovirus retinitis patients following allogeneic HSCT.
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影响因子：
1
作者：
Gupta, Mrinali Patel;Coombs, Peter;Kiss, Szilard
通讯作者：
Kiss, Szilard
影响因子：
--
作者：
HOLLAND, GN;BUHLES, WC;KAPLAN, HJ
通讯作者：
KAPLAN, HJ
影响因子：
15.8
作者：
Heiden, Daivd;Ford, Nathan;Wilson, David;Rodriguez, William R.;Margolis, Todd;Janssens, Bart;Bedelu, Martha;Tun, Nini;Goemaere, Eric;Saranchuk, Peter;Sabapathy, Kalpana;Smithuis, Frank;Luyirika, Emmanuel;Drew, W. Lawrence
通讯作者：
Drew, W. Lawrence
影响因子：
0.4
作者：
Haze, Masaya;Kobayashi, Takatoshi;Ikeda, Tsunehiko
通讯作者：
Ikeda, Tsunehiko
DOI：
10.1097/iae.0b013e318285f486
发表时间：
2013-10-01
影响因子：
3.3
作者：
Schneider, Eric W.;Elner, Susan G.;Johnson, Mark W.
通讯作者：
Johnson, Mark W.