Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits.
Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits.
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具有精神病性状的年轻人的杏仁核和前扣带回皮层的同理心反应能力。
DOI：
10.1111/jcpp.12063
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Blair RJ
中科院分区：
文献类型：
--
作者：
Marsh AA;Finger EC;Fowler KA;Adalio CJ;Jurkowitz IT;Schechter JC;Pine DS;Decety J;Blair RJ
精神病态特征与攻击性等反社会行为的增加有关，其特点是对他人痛苦的同情心减少。这表明精神病态特征也可能损害共情疼痛敏感性。然而，之前尚未评估过精神病态特征是否会影响对他人与自我痛苦的反应。我们使用全脑功能磁共振成像 (fMRI) 扫描来测量 14 名患有对立违抗障碍或品行障碍和精神病特征的青少年以及 21 名年龄、性别和智力相匹配的健康对照者的神经激活情况。当青少年观看引起疼痛的伤害的照片时，评估了与共情疼痛感知相关的结构的激活情况。青少年想象每张照片中的身体是他们自己的，或者它属于另一个人。使用随机效应方差分析来分析行为和神经影像数据。随着所描绘的疼痛的增加，具有精神病特征的青少年表现出与共情疼痛相关的区域的活动减少。这些区域包括前扣带皮层、腹侧纹状体（壳核）和杏仁核。当人们认为受伤发生在另一个人身上时，杏仁核活动就会减少。杏仁核和头侧前扣带皮层内的共情疼痛反应与 PCL:YV 评分所索引的精神病特征的严重程度呈负相关。随着对他人疼痛的感知强度的增加，具有精神病特征的青少年在与他人疼痛的情感反应有关的区域中表现出较低的反应性。此外，这种反应性的降低似乎可以预测症状的严重程度。
Psychopathic traits are associated with increases in antisocial behaviors such as aggression and are characterized by reduced empathy for others’ distress. This suggests that psychopathic traits may also impair empathic pain sensitivity. However, whether psychopathic traits affect responses to the pain of others versus the self has not been previously assessed. We used whole-brain functional magnetic resonance imaging (fMRI) scanning to measure neural activation in 14 adolescents with Oppositional Defiant Disorder or Conduct Disorder and psychopathic traits, as well as 21 healthy controls matched on age, sex, and intelligence. Activation in structures associated with empathic pain perception was assessed as adolescents viewed photographs of pain-inducing injuries. Adolescents imagined either that the body in each photograph was their own or that it belonged to another person. Behavioral and neuroimaging data were analyzed using random-effects analysis of variance. Youths with psychopathic traits showed reduced activity within regions associated with empathic pain as the depicted pain increased. These regions included rostral anterior cingulate cortex, ventral striatum (putamen), and amygdala. Reductions in amygdala activity particularly occurred when the injury was perceived as occurring to another. Empathic pain responses within both amygdala and rostral anterior cingulate cortex were negatively correlated with the severity of psychopathic traits as indexed by PCL:YV scores. Youths with psychopathic traits show less responsiveness in regions implicated in the affective response to another’s pain as the perceived intensity of this pain increases. Moreover, this reduced responsiveness appears to predict symptom severity.
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影响因子：
25
作者：
Buckholtz, Joshua W.;Treadway, Michael T.;Cowan, Ronald L.;Woodward, Neil D.;Benning, Stephen D.;Li, Rui;Ansari, M. Sib;Baldwin, Ronald M.;Schwartzman, Ashley N.;Shelby, Evan S.;Smith, Clarence E.;Cole, David;Kessler, Robert M.;Zald, David H.
通讯作者：
Zald, David H.
影响因子：
3.7
作者：
Decety, Jean;Michalska, Kalina J.
通讯作者：
Michalska, Kalina J.
影响因子：
6.7
作者：
Frick, Paul J;Dickens, Carrie
通讯作者：
Dickens, Carrie
影响因子：
--
作者：
Finger, Elizabeth C.;Marsh, Abigail A.;Blair, James R.
通讯作者：
Blair, James R.
DOI：
10.1111/j.1469-7610.2008.01905.x
发表时间：
2008-07-01
影响因子：
7.6
作者：
Herpertz, Sabine C.;Huebner, Thomas;Herpertz-Dahlmann, Beate
通讯作者：
Herpertz-Dahlmann, Beate