Is chloroquine chemoprophylaxis still effective to prevent low birth weight? Results of a study in Benin.
Is chloroquine chemoprophylaxis still effective to prevent low birth weight? Results of a study in Benin.
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DOI：
10.1186/1475-2875-6-27
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发表时间：
2007-03-06
期刊：
影响因子：
3
通讯作者：
Cot M
中科院分区：
文献类型：
--
作者：
Denoeud L;Fievet N;Aubouy A;Ayemonna P;Kiniffo R;Massougbodji A;Cot M
在传播稳定的地区，妊娠期疟疾与严重的孕产妇和胎儿结局，特别是低出生体重有关。为了预防这些并发症，在西非，每周一次的氯喹化学预防现在正被磺胺嘧啶-乙胺嘧啶间歇性预防治疗所取代。在贝宁评估了胎盘疟疾的流行率及其对低出生体重儿的负担，以评价在用间歇性预防性治疗取代每周CQ化学预防之前的疗效。2004年4月至2005年4月，在维达的两个产科诊所进行了一项观察性研究。在每次分娩时，检查胎盘血涂片是否感染疟疾，并询问妇女的妊娠史，包括CQ摄入量和剂量。在子样本（n = 166）的尿液中测量CQ。多元逻辑回归和线性回归用于评估与LBW和胎盘疟疾相关的因素。在1090例单胎活产婴儿中，胎盘疟疾和低出生体重儿的患病率分别为16%和17%。校正后，胎盘疟疾与LBW之间无显著相关性（校正OR = 1.43; P = 0.10）。多元线性回归分析显示，胎盘疟疾与孕妇出生体重下降呈正相关。超过98%的女性报告定期进行药物预防，在99%的尿液样本中可检测到CQ。在报告定期CQ预防的女性中，对LBW的保护作用较高，具有较强的持续时间-效应关系（线性趋势检验：P <0.001）。尽管高寄生虫的抵抗力和有限的效果，胎盘疟疾，CQ化学预防采取足够的剂量表明，仍然有效地减少低出生体重在贝宁。
In areas of stable transmission, malaria during pregnancy is associated with severe maternal and foetal outcomes, especially low birth weight (LBW). To prevent these complications, weekly chloroquine (CQ) chemoprophylaxis is now being replaced by intermittent preventive treatment with sulfadoxine-pyrimethamine in West Africa. The prevalence of placental malaria and its burden on LBW were assessed in Benin to evaluate the efficacy of weekly CQ chemoprophylaxis, prior to its replacement by intermittent preventive treatment. In two maternity clinics in Ouidah, an observational study was conducted between April 2004 and April 2005. At each delivery, placental blood smears were examined for malaria infection and women were interviewed on their pregnancy history including CQ intake and dosage. CQ was measured in the urine of a sub-sample (n = 166). Multiple logistic and linear regression were used to assess factors associated with LBW and placental malaria. Among 1090 singleton live births, prevalence of placental malaria and LBW were 16% and 17% respectively. After adjustment, there was a non-significant association between placental malaria and LBW (adjusted OR = 1.43; P = 0.10). Multiple linear regression showed a positive association between placental malaria and decreased birth weight in primigravidae. More than 98% of the women reported regular chemoprophylaxis and CQ was detectable in 99% of urine samples. Protection from LBW was high in women reporting regular CQ prophylaxis, with a strong duration-effect relationship (test for linear trend: P < 0,001). Despite high parasite resistance and limited effect on placental malaria, a CQ chemoprophylaxis taken at adequate doses showed to be still effective in reducing LBW in Benin.
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影响因子：
56.9
作者：
Fried, M;Duffy, PE
通讯作者：
Duffy, PE
DOI：
10.1016/s0035-9203(03)90012-5
发表时间：
2003-01-01
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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