Hippocampal inactivation during rearing on hind legs impairs spatial memory.
Hippocampal inactivation during rearing on hind legs impairs spatial memory.
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DOI：
10.1038/s41598-023-33209-9
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发表时间：
2023-04-15
影响因子：
4.6
通讯作者：
Newman, Ehren Lee
中科院分区：
文献类型：
--
作者：
Layfield, Dylan;Sidell, Nathan;Blankenberger, Kevin;Newman, Ehren Lee
空间记忆需要完整的海马体。运动和安静休息时期的海马功能（例如，美容和奖励消费）一直是广泛研究的目标。然而，在导航大鼠经常在他们的后腿，和海马活动的重要性，在这些期间的空间记忆的注意采样是未知的。为了解决这一问题，我们测试了背海马活动的必要性，在饲养时期的研究阶段的延迟胜利转移任务的记忆性能在随后的测试阶段。通过闭环、双侧、光遗传学失活来操纵海马活动。空间记忆的准确性显着和选择性降低时，背侧海马在编码饲养时期被灭活。这些数据表明，在饲养期间的海马活动可能是重要的空间记忆，揭示了一个新的联系海马功能在饲养和空间记忆的时期。
Spatial memory requires an intact hippocampus. Hippocampal function during epochs of locomotion and quiet rest (e.g., grooming and reward consumption) has been the target of extensive study. However, during navigation rats frequently rear up onto their hind legs, and the importance of hippocampal activity during these periods of attentive sampling for spatial memory is unknown. To address this, we tested the necessity of dorsal hippocampal activity during rearing epochs in the study phase of a delayed win-shift task for memory performance in the subsequent test phase. Hippocampal activity was manipulated with closed-loop, bilateral, optogenetic inactivation. Spatial memory accuracy was significantly and selectively reduced when the dorsal hippocampus was inactivated during rearing epochs at encoding. These data show that hippocampal activity during periods of rearing can be important for spatial memory, revealing a novel link between hippocampal function during epochs of rearing and spatial memory.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
2.5
作者：
HUGHES, RN
通讯作者：
HUGHES, RN
影响因子：
2.9
作者：
Hasselmo, ME;Bodelón, C;Wyble, BP
通讯作者：
Wyble, BP
DOI：
10.1162/netn_a_00024
发表时间：
2018
期刊：
Network neuroscience (Cambridge, Mass.)
影响因子：
--
作者：
Honey CJ;Newman EL;Schapiro AC
通讯作者：
Schapiro AC
影响因子：
56.9
作者：
BERRY, SD;THOMPSON, RF
通讯作者：
THOMPSON, RF