Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts.
Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts.
复制标题
DOI：
10.1371/journal.pone.0240198
复制
发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Hayashida N
中科院分区：
文献类型：
--
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nagata Y;Maeda T;Hayashida N
高血压常见于亚临床甲状腺功能减退症(SCH)。通过加强甲状腺炎症，抗过氧化物酶抗体(TPO-Ab)引起自身免疫性甲状腺炎，这是SCH最常见的原因之一。由于根据潜在的甲状腺损害的指征，TPO-Ab(+)与甲状腺囊肿的缺失有关，我们探讨了TPO-Ab、SCH、高血压和甲状腺囊肿之间潜在的联系机制。对1483名年龄在40-74岁的日本人进行了横断面研究。甲状腺囊肿定义为最大直径≥为2.0 mm，不含固体成分。TPO-Ab(+)与合并高血压的SCH呈正相关(调整优势比[OR]和95%可信区间[CI]，2.62[1.40，4.89])，而与无高血压的SCH无相关性(0.84[0.37，1.89])。此外，在没有甲状腺囊肿的参与者中，SCH与高血压呈正相关(2.15[1.23，3.76])，而在有甲状腺囊肿的参与者中，SCH与高血压无相关性(0.58[0.16，2.16])。TPO-Ab与有高血压的SCH呈正相关，与无高血压的SCH无相关性。此外，甲状腺囊肿的状况可能是SCH与高血压之间关系的决定性因素。这些发现是阐明SCH背后的背景机制的有效工具。
Hypertension frequently occurs in subclinical hypothyroidism (SCH). By bolstering thyroid inflammation, anti-peroxidase antibody (TPO-Ab) causes autoimmune thyroiditis, which is one of the most common causes of SCH. Since the absence of thyroid cysts is associated with TPO-Ab (+) based on the indication of latent thyroid damage, we explored the potential mechanism underlying the association among TPO-Ab, SCH, hypertension, and thyroid cysts. A cross-sectional study of 1,483 Japanese aged 40–74 years was conducted. Thyroid cysts were defined as those having a maximum diameter of ≥ 2.0 mm, containing no solid component. TPO-Ab (+) was positively associated with SCH with hypertension (adjusted odds ratio [OR] and 95% confidence interval [CI], 2.62 [1.40, 4.89]) but not with SCH without hypertension (0.84 [0.37, 1.89]), respectively. Moreover, among participants without thyroid cysts, SCH was positively associated with hypertension (2.15 [1.23, 3.76]) but not among participants with thyroid cysts (0.58 [0.16, 2.16]), respectively. TPO-Ab was positively associated with SCH with hypertension, but not with SCH without hypertension. In addition, status of thyroid cysts might act as a determinant factor on the association between SCH and hypertension. These findings are efficient tools to clarify the background mechanism that underlies SCH.
登录
查看更多内容
影响因子：
3.5
作者：
Carle, Allan;Laurberg, Peter;Pedersen, Inge Bulow
通讯作者：
Pedersen, Inge Bulow
影响因子：
8.6
作者：
Nielsen, Claus H.;Brix, Thomas H.;Hegedus, Laszlo
通讯作者：
Hegedus, Laszlo
影响因子：
4.1
作者：
Pietri, Panagiota;Vlachopoulos, Charalambos;Tousoulis, Dimitris
通讯作者：
Tousoulis, Dimitris
影响因子：
2.1
作者：
Mohanty, Shruti;Amruthlal, W.;Rao, Pragna
通讯作者：
Rao, Pragna
影响因子：
0.6
作者：
Abdulateef, Darya S.;Mahwi, Taha O.
通讯作者：
Mahwi, Taha O.