Reward enhances connectivity between the ventral striatum and the default mode network.
Reward enhances connectivity between the ventral striatum and the default mode network.
复制标题
奖赏增强了腹侧纹状体和默认模式网络之间的连接。
DOI：
10.1016/j.neuroimage.2022.119398
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发表时间：
2022-09
期刊：
影响因子：
5.7
通讯作者：
Smith, David V.
中科院分区：
文献类型：
--
作者：
Dobryakov, Ekaterin;Smith, David V.
默认模式网络（DMN）已被理论化为参与一系列社交、认知和情感功能。然而，之前的研究并没有考虑 DMN 如何根据心理背景对其他大脑区域做出贡献，从而使我们对 DMN 功能的理解不完整。我们通过将一种新颖的基于网络的心理生理相互作用（nPPI）分析应用于人类连接组项目中的奖励任务来解决这一差距。我们首先关注 DMN 和涉及前额皮质的其他网络的任务诱发反应，包括执行控制网络（显着性网络）和左右额顶叶网络。与许多先前的研究一致，DMN 在任务期间表现出激活相对减少，而其他网络在任务期间表现出相对增加。接下来，我们使用 nPPI 分析来评估这些网络与其他大脑区域的连接是否表现出任务依赖性变化。引人注目的是，我们发现奖励体验增强了 DMN 和腹侧纹状体之间的任务依赖性连接，这是 DMN 特有的效应。令人惊讶的是，DMN-VS 连接的强度与开放性相关的个性特征相关。总而言之，这些结果通过展示 DMN 在任务执行过程中如何对其他大脑系统做出贡献以及这些贡献如何与个体差异相关，从而推进了 DMN 模型。
The default mode network (DMN) has been theorized to participate in a range of social, cognitive, and affective functions. Yet, previous accounts do not consider how the DMN contributes to other brain regions depending on psychological context, thus rendering our understanding of DMN function incomplete. We addressed this gap by applying a novel network-based psychophysiological interaction (nPPI) analysis to the reward task within the Human Connectome Project. We first focused on the task-evoked responses of the DMN and other networks involving the prefrontal cortex, including the executive control network (salience network) and the left and right frontoparietal networks. Consistent with a host of prior studies, the DMN exhibited a relative decrease in activation during the task, while the other networks exhibited a relative increase during the task. Next, we used nPPI analyses to assess whether these networks exhibit task-dependent changes in connectivity with other brain regions. Strikingly, we found that the experience of reward enhances task-dependent connectivity between the DMN and the ventral striatum, an effect that was specific to the DMN. Surprisingly, the strength of DMN-VS connectivity was correlated with personality characteristics relating to openness. Taken together, these results advance models of DMN by demonstrating how it contributes to other brain systems during task performance and how those contributions relate to individual differences.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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