Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types.
Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types.
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DOI：
10.1016/j.neuron.2022.04.012
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发表时间：
2022-07-06
期刊：
影响因子：
16.2
通讯作者：
Schwartz, Gregory William
中科院分区：
文献类型：
--
作者：
Wienbar, Sophia;Schwartz, Gregory William
视网膜神经节细胞(RGC)是眼睛的尖峰投射神经元，编码视觉环境的不同特征。向不同类型的RGC提供突触输入以驱动特征选择性的电路已被广泛研究，但针对其内在特性及其如何影响特征选择性的研究较少。我们在小鼠中引入了一种RGC类型，即突发性对比抑制(BSbC)RGC，并将其与OFFsA进行了比较。它们的对比反应功能的不同不是由于突触输入的不同，而是它们的内在特性的不同。棘波的产生是这种功能差异背后的关键内在特性；bSbC RGC经历去极化阻断，而OFFsA RGC保持高尖峰频率。我们的结果表明，内在特性的差异允许这两种类型的RGC检测到相同视觉刺激的不同特征并将其传递到大脑。网络和固有特性都有助于感觉神经元如何编码刺激，但视网膜神经科学强调突触输入在控制视网膜神经节细胞(RGC)功能选择性方面的作用。Wienbar和Schwartz描述了RGC的特征，RGC经历了去极化阻塞来塑造其对对比的反应，展示了内在特性的关键作用。
Retinal ganglion cells (RGCs) are the spiking projection neurons of the eye that encode different features of the visual environment. The circuits providing synaptic input to different RGC types to drive feature selectivity have been studied extensively, but there has been less research aimed at understanding on the intrinsic properties and how they impact feature selectivity. We introduce an RGC type in the mouse, the Bursty Suppressed-by-Contrast (bSbC) RGC and compared it to the OFF sustained Alpha (OFFsA). Differences in their contrast response functions arose not from differences in synaptic inputs but in their intrinsic properties. Spike generation was the key intrinsic property behind this functional difference; the bSbC RGC undergoes depolarization block while the OFFsA RGC maintains a high spike rate. Our results demonstrate that differences in intrinsic properties allow these two RGC types to detect and relay distinct features of an identical visual stimulus to the brain. Network and intrinsic properties both contribute to how sensory neurons encode stimuli, but retinal neuroscience has emphasised synaptic inputs in controling retinal ganglion cell (RGC) feature selectivity. Wienbar and Schwartz characterize an RGC that undergoes depolarization block to shape its response to contrast demonstrating a critical role for intrinsic properties.
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DOI：
10.1016/j.cub.2016.05.035
发表时间：
2016-07-25
期刊：
Current biology : CB
影响因子：
--
作者：
Antinucci P;Suleyman O;Monfries C;Hindges R
通讯作者：
Hindges R
影响因子：
3.4
作者：
Browne L;Smith KE;Jagger DJ
通讯作者：
Jagger DJ
影响因子：
5.3
作者：
Höfflin F;Jack A;Riedel C;Mack-Bucher J;Roos J;Corcelli C;Schultz C;Wahle P;Engelhardt M
通讯作者：
Engelhardt M
影响因子：
5.5
作者：
HODGKIN, AL;HUXLEY, AF
通讯作者：
HUXLEY, AF
影响因子：
8.8
作者：
Emanuel, Alan J.;Kapur, Kush;Do, Michael Tri H.
通讯作者：
Do, Michael Tri H.