Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses.
Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses.
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DOI：
10.3390/cells12010195
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发表时间：
2023-01-03
期刊：
影响因子：
6
通讯作者：
Shafikhani, Sasha H.
中科院分区：
文献类型：
--
作者：
Wood, Stephen J.;Goldufsky, Josef W.;Seu, Michelle Y.;Dorafshar, Amir H.;Shafikhani, Sasha H.
关键词：
铜绿假单胞菌是一种致病性最强的革兰氏阴性细菌。它引起许多急性和慢性感染，发病率和死亡率高达40%。铜绿假单胞菌的致病性多功能性归功于大量的细胞相关和分泌的毒力因子，这些毒力因子使该病原体能够在宿主内的各种小生境中定殖并保护其免受宿主先天免疫防御。在感染过程中，诱导靶宿主细胞的细胞毒性是铜绿假单胞菌的主要毒力策略。铜绿假单胞菌在这一策略上投入了大量资金，这表现在大量的细胞毒素可以诱导靶宿主细胞中各种形式的细胞死亡。在这篇综述中，我们提供了一个深入的审查铜绿假单胞菌细胞毒素的基础上，其细胞毒性机制和可能的后果，其细胞毒性对宿主免疫反应。
Pseudomonas aeruginosa is one of the most virulent opportunistic Gram-negative bacterial pathogens in humans. It causes many acute and chronic infections with morbidity and mortality rates as high as 40%. P. aeruginosa owes its pathogenic versatility to a large arsenal of cell-associated and secreted virulence factors which enable this pathogen to colonize various niches within hosts and protect it from host innate immune defenses. Induction of cytotoxicity in target host cells is a major virulence strategy for P. aeruginosa during the course of infection. P. aeruginosa has invested heavily in this strategy, as manifested by a plethora of cytotoxins that can induce various forms of cell death in target host cells. In this review, we provide an in-depth review of P. aeruginosa cytotoxins based on their mechanisms of cytotoxicity and the possible consequences of their cytotoxicity on host immune responses.
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影响因子：
7
作者：
Balakrishnan A;Karki R;Berwin B;Yamamoto M;Kanneganti TD
通讯作者：
Kanneganti TD
影响因子：
4.5
作者：
Arnoldo A;Curak J;Kittanakom S;Chevelev I;Lee VT;Sahebol-Amri M;Koscik B;Ljuma L;Roy PJ;Bedalov A;Giaever G;Nislow C;Merrill AR;Lory S;Stagljar I
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Stagljar I
影响因子：
3.1
作者：
Arora, SK;Neely, AN;Ramphal, R
通讯作者：
Ramphal, R
影响因子：
6.4
作者：
Basso, Pauline;Ragno, Michel;Attree, Ina
通讯作者：
Attree, Ina
影响因子：
2.8
作者：
BALTCH, AL;SMITH, RP;LUTZ, F
通讯作者：
LUTZ, F