Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.
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用于三维细胞微环境工程的功能和仿生材料
DOI：
10.1021/acs.chemrev.7b00094
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发表时间：
2017-10-25
期刊：
影响因子：
62.1
通讯作者：
Xu F
中科院分区：
文献类型：
--
作者：
Huang G;Li F;Zhao X;Ma Y;Li Y;Lin M;Jin G;Lu TJ;Genin GM;Xu F
细胞微环境已成为细胞行为和功能在发育，生理学和病理生理学中的关键决定因素。细胞微环境中的细胞外基质（ECM）不仅作为细胞的结构基础，而且作为触发和调节细胞行为的三维（3D）生化和生物物理线索的来源。越来越多的证据表明，微环境的3D特性是体内观察到的许多关键细胞反应的发展所必需的，这推动了用于工程化3D细胞微环境的功能和仿生材料的开发。此类材料设计的进展改善了3D中细胞行为的控制，并推进了组织再生、体外组织模型、大规模细胞分化、免疫治疗和基因治疗等领域。然而，该领域仍处于起步阶段，关于细胞-微环境相互作用性质的发现继续推翻该领域的许多早期进展。关键的挑战仍然是解剖化学，结构，力学和电生理学在细胞微环境中的作用，并理解和利用这些因素中的周期性和漂移的作用。这篇评论概括了最近的进展似乎离开了不断变化的最新技术水平，并强调了仍然存在巨大潜力和不确定性的领域。细胞微环境已成为细胞行为和功能在发育，生理学和病理生理学中的关键决定因素。细胞微环境中的细胞外基质（ECM）不仅作为细胞的结构基础，而且作为触发和调节细胞行为的三维（3D）生化和生物物理线索的来源。越来越多的证据表明，微环境的3D特性是体内观察到的许多关键细胞反应的发展所必需的，这推动了用于工程化3D细胞微环境的功能和仿生材料的开发。此类材料设计的进展改善了3D中细胞行为的控制，并推进了组织再生、体外组织模型、大规模细胞分化、免疫治疗和基因治疗等领域。然而，该领域仍处于起步阶段，关于细胞-微环境相互作用性质的发现继续推翻该领域的许多早期进展。关键的挑战仍然是解剖化学，结构，力学和电生理学在细胞微环境中的作用，并理解和利用这些因素中的周期性和漂移的作用。这篇评论概括了最近的进展似乎离开了不断变化的最新技术水平，并强调了仍然存在巨大潜力和不确定性的领域。
The cell microenvironment has emerged as a key determinant of cell behavior and function in development, physiology, and pathophysiology. Extracellular matrix (ECM) within the cell microenvironment serves not only as a structural foundation for cells, but also as a source of three-dimensional (3D) biochemical and biophysical cues that trigger and regulate cell behaviors. Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, fueling a surge in the development of functional and biomimetic materials for engineering the 3D cell microenvironment. Progress in the design of such materials has improved control of cell behaviors in 3D and advanced the fields of tissue regeneration, in vitro tissue models, large-scale cell differentiation, immunotherapy, and gene therapy. However, the field is still in its infancy, and discoveries about the nature of cell-microenvironment interactions continue to overturn much early progress in the field. Key challenges continue to be dissecting the roles of chemistry, structure, mechanics, and electrophysiology in the cell microenvironment, and understanding and harnessing the roles of periodicity and drift in these factors. This review encapsulates where recent advances appear to leave the ever-shifting state of the art, and highlights areas in which substantial potential and uncertainty remain. The cell microenvironment has emerged as a key determinant of cell behavior and function in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the cell microenvironment serves not only as a structural foundation for cells but also as a source of three-dimensional (3D) biochemical and biophysical cues that trigger and regulate cell behaviors. Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, fueling a surge in the development of functional and biomimetic materials for engineering the 3D cell microenvironment. Progress in the design of such materials has improved control of cell behaviors in 3D and advanced the fields of tissue regeneration, in vitro tissue models, large-scale cell differentiation, immunotherapy, and gene therapy. However, the field is still in its infancy, and discoveries about the nature of cell–microenvironment interactions continue to overturn much early progress in the field. Key challenges continue to be dissecting the roles of chemistry, structure, mechanics, and electrophysiology in the cell microenvironment, and understanding and harnessing the roles of periodicity and drift in these factors. This review encapsulates where recent advances appear to leave the ever-shifting state of the art, and it highlights areas in which substantial potential and uncertainty remain.
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影响因子：
3.4
作者：
Ali, Zubaidah Mohammed;Gibson, Lorna J.
通讯作者：
Gibson, Lorna J.
DOI：
10.1115/1.4024460
发表时间：
2013-07-01
影响因子：
1.7
作者：
Aghvami, Maziar;Barocas, V. H.;Sander, E. A.
通讯作者：
Sander, E. A.
DOI：
10.1039/c5ib00040h
发表时间：
2015-10
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Acerbi I;Cassereau L;Dean I;Shi Q;Au A;Park C;Chen YY;Liphardt J;Hwang ES;Weaver VM
通讯作者：
Weaver VM
影响因子：
64.5
作者：
Altschuler SJ;Wu LF
通讯作者：
Wu LF
分化细胞的表型性状丧失。 3。软骨细胞在原发性培养物中的可逆行为。
影响因子：
7.8
作者：
Abbott, J;Holtzer, H
通讯作者：
Holtzer, H