Age-dependent associations between telomere length and environmental conditions in roe deer.
Age-dependent associations between telomere length and environmental conditions in roe deer.
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DOI：
10.1098/rsbl.2017.0434
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发表时间：
2017-09
期刊：
影响因子：
3.3
通讯作者：
Nussey DH
中科院分区：
文献类型：
--
作者：
Wilbourn RV;Froy H;McManus MC;Cheynel L;Gaillard JM;Gilot-Fromont E;Regis C;Rey B;Pellerin M;Lemaître JF;Nussey DH
端粒长度(Tl)是一种很有前途的生物标记物，可以用来反映整体的生理状态和过去的环境经验，有助于我们理解自然种群生活史变异的驱动因素。越来越多的鸟类研究表明，环境压力或恶劣的环境条件与TL缩短有关，但在野生哺乳动物中缺乏这种关系的研究。在这里，我们比较了来自经历不同环境条件的两个法国种群的横断面样本中的白细胞TL。我们发现，正如预测的那样，在经历恶劣环境条件的人群中，TL较短，但这种差异仅在年龄较大的个体中显著，并且与性别和体重无关。出乎意料的是，在环境条件良好的人群中，TL随着年龄的增加而显著增加，而在环境条件较差的人群中，TL与年龄没有明显的关系。这些结果证明了自然哺乳动物群体中端粒动力学的环境敏感性和复杂性，并突显了纵向数据对于解开产生端粒的个体内和个体之间过程的重要性。
Telomere length (TL) represents a promising biomarker of overall physiological state and of past environmental experiences, which could help us understand the drivers of life-history variation in natural populations. A growing number of studies in birds suggest that environmental stress or poor environmental conditions are associated with shortened TL, but studies of such relationships in wild mammals are lacking. Here, we compare leucocyte TL from cross-sectional samples collected from two French populations of roe deer which experience different environmental conditions. We found that, as predicted, TL was shorter in the population experiencing poor environmental conditions but that this difference was only significant in older individuals and was independent of sex and body mass. Unexpectedly, the difference was underpinned by a significant increase in TL with age in the population experiencing good environmental conditions, while there was no detectable relationship with age in poor conditions. These results demonstrate both the environmental sensitivity and complexity of telomere dynamics in natural mammal populations, and highlight the importance of longitudinal data to disentangle the within- and among-individual processes that generate them.
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野生哺乳动物中免疫细胞端粒长度与年龄相关的下降和与疾病相关的变化。
影响因子：
3.7
作者：
Beirne C;Delahay R;Hares M;Young A
通讯作者：
Young A
DOI：
10.1038/nrg3246
发表时间：
2012-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Gaillard, Jean-Michel;Hewison, A. J. Mark;Bonenfant, Christophe
通讯作者：
Bonenfant, Christophe
影响因子：
3.3
作者：
Salmon, P.;Nilsson, J. F.;Isaksson, C.
通讯作者：
Isaksson, C.
影响因子：
4.9
作者：
Watson RL;Bird EJ;Underwood S;Wilbourn RV;Fairlie J;Watt K;Salvo-Chirnside E;Pilkington JG;Pemberton JM;McNeilly TN;Froy H;Nussey DH
通讯作者：
Nussey DH