Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.
Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.
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DOI：
10.1016/j.schres.2020.09.008
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发表时间：
2020-10
影响因子：
4.5
通讯作者：
Kikinis Z
中科院分区：
文献类型：
--
作者：
Heller C;Steinmann S;Levitt JJ;Makris N;Antshel KM;Fremont W;Coman IL;Schweinberger SR;Weiß T;Bouix S;Kubicki MR;Kates WR;Kikinis Z
额-纹状体-丘脑（FST）子回路的异常存在于精神分裂症中，并与认知障碍相关。然而，它仍然是未知的异常FST子电路是否存在于精神病发作之前。这可以通过研究22q11.2缺失综合征（22 q11 DS）来阐明，22 q11 DS是一种遗传综合征，与成年期发生精神分裂症的30%风险和精神病发作前言语智商（VIQ）下降相关。在这里，我们研究了白色物质（WM）束FST子电路，特别是那些在背外侧（DLPFC）和腹外侧前额叶皮层（VLPFC）子电路，和他们的关联与VIQ的年轻人与22 q11 DS。对21例有精神分裂症前驱症状的22 q11 DS患者、30例无前驱症状的22 q11 DS患者和30例健康对照者（平均年龄：21±2岁）进行弥散MRI扫描。用额中回（rMFG）和额下回（IFG）分别代表DLPFC和VLPFC，在纹状体和丘脑之间重建WM束。使用各向异性分数（FA）和径向扩散率（RD）进行组间比较。VIQ进行了评估，并与扩散措施进行了评价。22 q11 DS中DLPFC和VLPFC子回路的大部分区域FA显着增加，RD减少。在有前驱症状的22 q11 DS中，言语智商得分与FA呈负相关，在趋势水平上与右侧丘脑-IFG束的RD呈正相关。虽然FST子电路的异常与精神分裂症有关，我们观察到，这些异常也存在于22 q11 DS个人前驱症状，并与右丘脑IFG道的言语表现。
Abnormalities in fronto-striatal-thalamic (FST) sub-circuits are present in schizophrenia and are associated with cognitive impairments. However, it remains unknown whether abnormalities in FST sub-circuits are present before psychosis onset. This may be elucidated by investigating 22q11.2 deletion syndrome (22q11DS), a genetic syndrome associated with a 30% risk for developing schizophrenia in adulthood and a decline in Verbal IQ (VIQ) preceding psychosis onset. Here we examined white matter (WM) tracts in FST sub-circuits, especially those in the dorsolateral (DLPFC) and ventrolateral prefrontal cortex (VLPFC) sub-circuits, and their associations with VIQ in young adults with 22q11DS. Diffusion MRI scans were acquired from 21 individuals with 22q11DS with prodromal symptoms of schizophrenia, 30 individuals with 22q11DS without prodromal symptoms, and 30 healthy controls (mean age: 21±2 years). WM tracts were reconstructed between striatum and thalamus with rostral middle frontal gyrus (rMFG) and inferior frontal gyrus (IFG), representing DLPFC and VLPFC respectively. Fractional anisotropy (FA) and radial diffusivity (RD) were used for group comparisons. VIQ was assessed and associations with the diffusion measures were evaluated. FA was significantly increased and RD decreased in most tracts of the DLPFC and VLPFC sub-circuits in 22q11DS. Verbal IQ scores correlated negatively with FA and, at trend level, positively with RD in the right thalamus-IFG tract in 22q11DS with prodromal symptoms. While abnormalities in FST sub-circuits are associated with schizophrenia, we observed that these abnormalities are also present in 22q11DS individuals with prodromal symptoms and are associated with verbal performance in the right thalamus-IFG tract.
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影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
4.5
作者：
Bleich-Cohen, Maya;Sharon, Haggai;Hendler, Talma
通讯作者：
Hendler, Talma
影响因子：
5.4
作者：
de Leeuw M;Bohlken MM;Mandl RC;Kahn RS;Vink M
通讯作者：
Vink M
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.5
作者：
Gold, JM
通讯作者：
Gold, JM