Drug-induced granulomatous interstitial nephritis in a patient with ankylosing spondylitis during therapy with adalimumab.
Drug-induced granulomatous interstitial nephritis in a patient with ankylosing spondylitis during therapy with adalimumab.
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药物诱导的在用adalimumab治疗期间的强直性脊柱炎患者的肉芽肿性间质肾炎。
DOI：
10.1053/j.ajkd.2010.08.019
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Müller GA
中科院分区：
文献类型：
--
作者：
Korsten P;Sweiss NJ;Nagorsnik U;Niewold TB;Gröne HJ;Gross O;Müller GA
肿瘤坏死因子α (TNF-α)抑制剂用于治疗类风湿性关节炎、牛皮癣、银屑病关节炎、克罗恩病、强直性脊柱炎和青少年特发性关节炎。TNF抑制剂的使用与自身免疫的诱导相关（系统性红斑狼疮、血管炎、牛皮癣和结节病/结节样肉芽肿）。我们报告一个强直性脊柱炎患者在接受阿达木单抗治疗18个月后出现间质性肉芽肿性肾炎病例。先前报道的使用TNF-α抑制剂继发的结节样反应涉及肝脏、肺、淋巴结、中枢神经系统和皮肤。阿达木单抗治疗后肉芽肿性肾炎未见报道。需要密切观察接受TNF抑制剂治疗的患者自身免疫体征和症状的演变。器官受累是不可预测的，这使得正确的诊断和治疗极具挑战性。
Tumor necrosis factor α (TNF-α) inhibitors are used in the treatment of rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn disease, ankylosing spondylitis, and juvenile idiopathic arthritis. Use of TNF inhibitors is associated with the induction of autoimmunity (systemic lupus erythematosus, vasculitis, psoriasis, and sarcoidosis/sarcoid-like granulomas). We report a case of interstitial granulomatous nephritis in a patient with ankylosing spondylitis after 18 months of treatment with adalimumab. Previously reported cases of sarcoid-like reactions secondary to the use of TNF-α inhibitors involved the liver, lung, lymph nodes, central nervous system, and skin. Granulomatous nephritis after adalimumab treatment has not been described. Close observation of patients undergoing treatment with TNF inhibitors for evolving signs and symptoms of autoimmunity is required. Organ involvement is unpredictable, which makes correct diagnosis and management extremely challenging.
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影响因子：
3.4
作者：
Ahmed, M. Mubashir;Mubashir, Eisha;Dossabhoy, Neville R.
通讯作者：
Dossabhoy, Neville R.
DOI：
10.4049/jimmunol.182.1.34
发表时间：
2009-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kariuki SN;Kirou KA;MacDermott EJ;Barillas-Arias L;Crow MK;Niewold TB
通讯作者：
Niewold TB
影响因子：
13.6
作者：
Ramos-Casals, Manuel;Roberto-Perez-Alvarez;Khamashta, Munther A.
通讯作者：
Khamashta, Munther A.
影响因子：
1.2
作者：
Ishiguro, Takashi;Takayanagi, Noboru;Kawabata, Yoshinori
通讯作者：
Kawabata, Yoshinori
影响因子：
7.8
作者：
Kariuki, Silvia N.;Niewold, Timothy B.
通讯作者：
Niewold, Timothy B.