Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain.
Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain.
复制标题
慢性炎性疼痛大鼠伽马振荡活动增强
DOI：
10.3389/fnins.2016.00489
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发表时间：
2016
影响因子：
4.3
通讯作者：
Wan Y
中科院分区：
文献类型：
--
作者：
Wang J;Wang J;Xing GG;Li X;Wan Y
据报道，振荡γ活动参与短暂的急性疼痛和强直性持续疼痛。由于慢性疼痛是一种以持续性疼痛为特征的更严重的病理状态，因此确定γ活性是否参与慢性疼痛是非常有趣的。为了研究慢性疼痛中的振荡γ活动，在本研究中，我们记录了自发性皮质电图（ECoG）信号在慢性疼痛的发展过程中，大鼠慢性炎症疼痛诱导的单关节炎。ECoG数据的功率谱分析显示，在慢性炎性疼痛的晚期，γ功率显著增加。增加的γ活动主要发生在初级躯体感觉皮层的电极上。在慢性疼痛的大鼠中，γ功率与通过引起后爪缩回反应的激光能量测量的痛觉过敏呈正相关。此外，在慢性炎性疼痛条件下观察到伽马功率的振幅和θ振荡的相位之间的耦合增加。这些结果表明慢性疼痛中自发γ活动增强，并提示慢性疼痛严重程度的潜在生物标志物。
It has been reported that oscillatory gamma activity participates in brief acute pain and tonic ongoing pain. It is of great interest to determine whether the gamma activity is involved in chronic pain since chronic pain is a more severe pathological condition characterized by pain persistency. To investigate the oscillatory gamma activity in chronic pain, in the present study, we recorded spontaneous electrocorticogram (ECoG) signals during chronic pain development in rats with chronic inflammatory pain induced by monoarthritis. Power spectrum analysis of ECoG data showed that gamma power increased significantly at the late stage of chronic inflammatory pain. The increased gamma activity occurred mainly at electrodes over primary somatosensory cortices. In rats with chronic pain, the gamma power was positively correlated with the hyperalgesia measured by laser energy that elicited hindpaw withdrawal response. Furthermore, an increased coupling between the amplitude of gamma power and the phase of theta oscillations was observed in chronic inflammatory pain condition. These results indicate an enhanced spontaneous gamma activity in chronic pain and suggest a potential biomarker for the severity of chronic pain.
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