Changes of spontaneous oscillatory activity to tonic heat pain.
Changes of spontaneous oscillatory activity to tonic heat pain.
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自发性振荡活性对补品热痛的变化。
DOI：
10.1371/journal.pone.0091052
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Peng W;Hu L;Zhang Z;Hu Y
短暂的疼痛刺激可以引起α振荡活动的抑制和γ振荡活动的增强，这也可以很大程度上受到注意的调制。在这里，我们试图描述紧张性热疼痛感知过程中皮质活动的变化，并研究了定向/分心对这些反应的影响。我们从38名健康志愿者中收集了5分钟长的连续脑电图（EEG）数据，这些数据以平衡顺序呈现：（A）静息状态;（B）无害分心状态;（C）有害分心状态;（D）有害关注状态。通过比较四种实验条件下脑电功率谱的差异以及谱功率差与主观疼痛强度的关系，研究了热刺激和选择注意对振荡活动的影响。条件D下振荡活动的变化特征是对侧-中央电极α振荡功率稳定持续下降，γ振荡功率普遍增加，且与主观疼痛强度显著相关。由于注意力以不同的方式影响α和γ频段的EEG反应，因此它们可能与疼痛的多维感觉体验的不同方面有关。观察到的对侧-中枢α抑制（条件D与B和D与C）可能主要反映了自上而下的认知过程，如注意力，而广泛的γ增强（条件D与A）可能部分反映了强直性疼痛处理，代表了自下而上的刺激相关和自上而下的受试者驱动的认知过程的汇总效应。
Transient painful stimuli could induce suppression of alpha oscillatory activities and enhancement of gamma oscillatory activities that also could be greatly modulated by attention. Here, we attempted to characterize changes in cortical activities during tonic heat pain perception and investigated the influence of directed/distracted attention on these responses. We collected 5-minute long continuous Electroencephalography (EEG) data from 38 healthy volunteers during four conditions presented in a counterbalanced order: (A) resting condition; (B) innoxious-distracted condition; (C) noxious-distracted condition; (D) noxious-attended condition. The effects of tonic heat pain stimulation and selective attention on oscillatory activities were investigated by comparing the EEG power spectra among the four experimental conditions and assessing the relationship between spectral power difference and subjective pain intensity. The change of oscillatory activities in condition D was characterized by stable and persistent decrease of alpha oscillation power over contralateral-central electrodes and widespread increase of gamma oscillation power, which were even significantly correlated with subjective pain intensity. Since EEG responses in the alpha and gamma frequency band were affected by attention in different manners, they are likely related to different aspects of the multidimensional sensory experience of pain. The observed contralateral-central alpha suppression (conditions D vs. B and D vs. C) may reflect primarily a top-down cognitive process such as attention, while the widespread gamma enhancement (conditions D vs. A) may partly reflect tonic pain processing, representing the summary effects of bottom-up stimulus-related and top-down subject-driven cognitive processes.
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