Resting-sate functional reorganization of the rat limbic system following neuropathic injury.
Resting-sate functional reorganization of the rat limbic system following neuropathic injury.
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DOI：
10.1038/srep06186
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发表时间：
2014-09-02
影响因子：
4.6
通讯作者：
Apkarian AV
中科院分区：
文献类型：
--
作者：
Baliki MN;Chang PC;Baria AT;Centeno MV;Apkarian AV
来自不同临床队列的人脑成像研究表明，慢性疼痛与大规模的脑功能和形态重组有关。然而，大鼠全脑网络如何在拓扑上重组以支持神经病理损伤后持续的疼痛样行为仍是未知的。在这里，我们比较了接受备用神经损伤(SNI)的大鼠与假损伤大鼠在损伤后5天(n=11；n=12 Sham)和28天(n=11 SNI；n=12 Sham)的静息状态下基于功能连接的全脑网络特性。与人类相似，大鼠大脑的拓扑特性表现出小世界的特征，在SNI和Sham之间没有区别。SNI动物的局部神经网络在损伤后第5天显示最小的破坏，在第28天显示更广泛的重组。SNI后28天，功能性连接改变主要局限于边缘系统内，以及边缘系统和伤害性感觉系统之间。没有观察到伤害性网络内的连通性变化。此外，这些变化是偏侧化的，并与SNI动物表现出的触觉异常痛成比例。这些发现证实SNI主要与边缘区域的信息传递改变有关，并为理解脑功能重组对持续性神经病理性损伤的反应提供了一个新的翻译框架。
Human brain imaging studies from various clinical cohorts show that chronic pain is associated with large-scale brain functional and morphological reorganization. However, how the rat whole-brain network is topologically reorganized to support persistent pain-like behavior following neuropathic injury remains unknown. Here we compare resting state fMRI functional connectivity-based whole-brain network properties between rats receiving spared nerve injury (SNI) vs. sham injury, at 5 days (n = 11 SNI; n = 12 sham) and 28 days (n = 11 SNI; n = 12 sham) post-injury. Similar to the human, the rat brain topological properties exhibited small world features and did not differ between SNI and sham. Local neural networks in SNI animals showed minimal disruption at day 5, and more extensive reorganization at day 28 post-injury. Twenty-eight days after SNI, functional connection changes were localized mainly to within the limbic system, as well as between the limbic and nociceptive systems. No connectivity changes were observed within the nociceptive network. Furthermore, these changes were lateralized and in proportion to the tactile allodynia exhibited by SNI animals. The findings establish that SNI is primarily associated with altered information transfer of limbic regions and provides a novel translational framework for understanding brain functional reorganization in response to a persistent neuropathic injury.
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影响因子：
2.5
作者：
Farmer MA;Baliki MN;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
3.7
作者：
Humphries MD;Gurney K
通讯作者：
Gurney K
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
14.5
作者：
Hashmi, Javeria A.;Baliki, Marwan N.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania