VEGF Signaling in Neurological Disorders.
VEGF Signaling in Neurological Disorders.
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DOI：
10.3390/ijms19010275
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发表时间：
2018-01-17
影响因子：
5.6
通讯作者：
Madsen JR
中科院分区：
文献类型：
--
作者：
Shim JW;Madsen JR
血管内皮生长因子（VEGF）是一种有效的生长因子，在血管生成和血管生成中发挥多种作用。在大脑中，VEGF 介导血管生成、神经迁移和神经保护。作为渗透性因子，过量的 VEGF 会破坏细胞内屏障，增加脉络丛内皮细胞的渗漏，引起水肿，并激活炎症通路。最近，我们发现肝素结合表皮生长因子如生长因子 (HB-EGF)——一类 EGF 受体 (EGFR) 家族配体——通过激活 VEGF 信号传导导致脑积水伴蛛网膜下腔出血的发生。本综述的目的是更新涉及脑血管和年龄相关神经系统疾病的神经系统疾病导致的死亡原因，并了解用 VEGF 拮抗剂治疗血管生成依赖性病理事件的机制。全球疾病负担研究表明，癌症和心血管疾病（包括缺血性和出血性中风）是全球死亡的两大主要原因。文献表明，缺血性大脑中的 VEGF 信号传导凸显了调节 VEGF 信号传导途径的浓度、时间和替代途径的重要性。区分 VEGF 信号传导两种不同途径的分子靶标可能为治疗神经系统疾病和保持较低的死亡率提供新的疗法。
Vascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of the choroid plexus endothelia, evokes edema, and activates the inflammatory pathway. Recently, we discovered that a heparin binding epidermal growth factor like growth factor (HB-EGF)—a class of EGF receptor (EGFR) family ligands—contributes to the development of hydrocephalus with subarachnoid hemorrhage through activation of VEGF signaling. The objective of this review is to entail a recent update on causes of death due to neurological disorders involving cerebrovascular and age-related neurological conditions and to understand the mechanism by which angiogenesis-dependent pathological events can be treated with VEGF antagonisms. The Global Burden of Disease study indicates that cancer and cardiovascular disease including ischemic and hemorrhagic stroke are two leading causes of death worldwide. The literature suggests that VEGF signaling in ischemic brains highlights the importance of concentration, timing, and alternate route of modulating VEGF signaling pathway. Molecular targets distinguishing two distinct pathways of VEGF signaling may provide novel therapies for the treatment of neurological disorders and for maintaining lower mortality due to these conditions.
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影响因子：
6.3
作者：
Deshpande, Abhishek;Dombrowski, Stephen M.;Luciano, Mark G.
通讯作者：
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影响因子：
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作者：
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Mukhopadhyay, D
DOI：
10.1152/ajpregu.90502.2008
发表时间：
2009-07-01
影响因子：
2.8
作者：
Bhargava, Pankaj
通讯作者：
Bhargava, Pankaj
影响因子：
11
作者：
GODWINAUSTEN, RB;LEE, PN;STERN, GM
通讯作者：
STERN, GM