Prolonged viral shedding and antibody persistence in patients with COVID-19.
Prolonged viral shedding and antibody persistence in patients with COVID-19.
复制标题
DOI：
10.1016/j.micinf.2021.104810
复制
发表时间：
2021-05
影响因子：
5.8
通讯作者：
Ramezani A
中科院分区：
文献类型：
--
作者：
Fotouhi F;Salehi-Vaziri M;Farahmand B;Mostafavi E;Pouriayevali MH;Jalali T;Mazaheri V;Sadat Larijani M;Tavakoli M;Eshratkhah Mohammadnejad A;Afzali N;Zokaei A;Hosseini S;Mortazavipour MM;Oskouei F;Ramezani A
SARS-CoV-2作为一种新的全球威胁，已经影响了全球人口一年。尽管努力根除这种感染，仍然存在一些挑战，包括不同的病毒表现，感染个体的时间免疫和病毒脱落的可变数据。我们研究了255例COVID-19疑似病例，以评估病例中病毒脱落时间和SARS-CoV-2抗体的产生。采用实时RT-PCR法检测病毒存在，采用SARS-CoV-2 IgM和IgG试剂盒检测SARS-CoV-2抗体。确诊新冠肺炎患者113例。随访患者至PCR阴性。研究人群的病毒脱落中位数为34.16（±17.65）天，与年龄、性别和基础疾病无显著相关性。在感染的长期形式中发现了颤抖和身体疼痛，并且有胃肠道问题的患者也经历了更长时间的病毒脱落。此外，在150天后，84%的患者体内存在IgG。根据这些数据，病毒脱落时间的中位数为34.16天，这表明14天的隔离可能不足以对群体进行隔离。此外，IgG分析表明，它在大多数患者中持续存在近6个月，这给疫苗的疗效和应用带来了一些希望。
SARS-CoV-2 as a new global threat has affected global population for one year. Despite the great effort to eradicate this infection, there are still some challenges including different viral presentation, temporal immunity in infected individuals and variable data of viral shedding. We studied 255 COVID-19 suspected individuals to assess the viral shedding duration and also the antibody development against SARS-CoV-2 among the cases. Real Time RT-PCR assay was applied to determine the virus presence and SARS-CoV-2 antibodies were evaluated using SARS-CoV-2 IgM and IgG kits. 113 patients were confirmed for COVID-19 infection. The patients were followed until negative PCR achieved. The median viral shedding among studied population was obtained 34.16 (±17.65) days which was not significantly associated with age, sex and underlying diseases. Shiver and body pain were found in prolonged form of the infection and also patients who had gastrointestinal problems experienced longer viral shedding. Moreover, IgG was present in 84% of patients after 150 days. According to this data, the median viral shedding prolongation was 34.16 days which indicates that 14 days isolation might not be enough for population. In addition, IgG profiling indicated that it is persistent in a majority of patients for nearly 6 months which has brought some hopes in vaccine efficacy and application.
登录
查看更多内容
影响因子：
2.6
作者：
Sadat SM;Aghadadeghi MR;Yousefi M;Khodaei A;Sadat Larijani M;Bahramali G
通讯作者：
Bahramali G
影响因子：
5.4
作者：
Figueiredo-Campos P;Blankenhaus B;Mota C;Gomes A;Serrano M;Ariotti S;Costa C;Nunes-Cabaço H;Mendes AM;Gaspar P;Pereira-Santos MC;Rodrigues F;Condeço J;Escoval MA;Santos M;Ramirez M;Melo-Cristino J;Simas JP;Vasconcelos E;Afonso Â;Veldhoen M
通讯作者：
Veldhoen M
影响因子：
2.7
作者：
Tan, An Sen;Nerurkar, Sanjna Nilesh;Poh Sheng Yeong, Joe
通讯作者：
Poh Sheng Yeong, Joe
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC
影响因子：
82.9
作者：
He, Xi;Lau, Eric H. Y.;Leung, Gabriel M.
通讯作者：
Leung, Gabriel M.