LifeGene--a large prospective population-based study of global relevance.
LifeGene--a large prospective population-based study of global relevance.
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DOI：
10.1007/s10654-010-9521-x
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发表时间：
2011-01
影响因子：
13.6
通讯作者：
Pedersen NL
中科院分区：
文献类型：
--
作者：
Almqvist C;Adami HO;Franks PW;Groop L;Ingelsson E;Kere J;Lissner L;Litton JE;Maeurer M;Michaëlsson K;Palmgren J;Pershagen G;Ploner A;Sullivan PF;Tybring G;Pedersen NL
研究基因与环境的相互作用需要生活方式数据的数量和质量与相应基因组数据的数量和质量相当。瑞典拥有进行全面纵向生物医学研究的几个关键先决条件，例如个人身份号码、普遍可用的国家医疗保健系统、不断更新的人口和健康登记以及具有科学动机的人口。 LifeGene 立足于这些优势，通过在研究友好型环境中的独特设计，弥合基础研究和临床应用之间的差距，特别关注人群。 LifeGene 被设计为一项前瞻性队列研究，也是一个基础设施，大约每 5 年与研究参与者进行一次重复接触。将招募 18 至 45 岁的索引人员，并邀请其家庭成员（伴侣和任何子女）加入。将通过网络进行一份针对尖端研究问题的综合调查问卷，并每年进行简短的跟进。还将在基线时收集生物样本和物理测量结果，并在此后每 5 年重新进行一次。基于事件的采样将是 LifeGene 的一个关键功能。以家庭为基础的设计将为年轻夫妇提供在怀孕前和怀孕期间参与的机会，从而允许对出生在具有来自母亲和父亲的完整产前和围产期数据的队列中的儿童进行首次研究。问题和抽样方案将根据参与者的年龄和生活事件量身定制。 LifeGene 的目标是招募 500,000 名瑞典人，并纵向跟踪他们至少 20 年。
Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18–45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants’ age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.
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