Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes
复制标题
流感病毒的不同亚型针对不同的人类蛋白质和导致不同致病表型的途径
DOI：
10.1155/2019/4794910
复制
发表时间：
2019-10
影响因子：
--
通讯作者：
Liang Long
中科院分区：
文献类型：
--
作者：
Wang Yujie;Song Ting;Li Kaiwu;Jin Yuan;Yue Junjie;Ren Hongguang;Liang Long
Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide insights into the pathogenic mechanisms of the virus. In this paper, we found that the same proteins (nucleoprotein and neuraminidase) of H1N1 and H5N1 have different impacts on the NF-κB activation. By further examining the virus–host protein–protein interactions, we found that both NP and NA proteins of the H1N1 and H5N1 viruses target different host proteins. These results indicate that different subtypes of influenza viruses target different human proteins and pathways leading to different pathogenic phenotypes.
登录
查看更多内容
影响因子：
3.7
作者：
Reis AL;McCauley JW
通讯作者：
McCauley JW
影响因子：
5.4
作者：
Zhou, Jiyong;Sun, Wenbo;Chen, Hualan
通讯作者：
Chen, Hualan
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
6.7
作者：
Tong S;Zhu X;Li Y;Shi M;Zhang J;Bourgeois M;Yang H;Chen X;Recuenco S;Gomez J;Chen LM;Johnson A;Tao Y;Dreyfus C;Yu W;McBride R;Carney PJ;Gilbert AT;Chang J;Guo Z;Davis CT;Paulson JC;Stevens J;Rupprecht CE;Holmes EC;Wilson IA;Donis RO
通讯作者：
Donis RO
影响因子：
7.2
作者：
Oeckinghaus, Andrea;Ghosh, Sankar
通讯作者：
Ghosh, Sankar