Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China.

Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China.
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评估中国上海轻度 COVID-19 康复患者的临床特征与中和抗体水平的关联

DOI:
10.1001/jamainternmed.2020.4616
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发表时间:
2020-10-01
影响因子:
39
通讯作者:
--
中科院分区:
医学1区
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--
作者:

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2019年新型冠状病毒病(COVID-19)康复患者的临床特征是否与中和抗体水平相关?在这项对175名从轻度COVID-19中康复的患者进行的队列研究中,严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)的中和抗体滴度在出院时变化很大。此外,10例患者未检测到中和抗体。需要进一步的研究来了解不同水平的SARS-CoV-2特异性中和抗体对预防未来SARS-CoV-2感染的影响。
Key Points Question Are clinical characteristics of patients who recovered from mild coronavirus disease 2019 (COVID-19) associated with levels of neutralizing antibodies? Findings In this cohort study of 175 patients who recovered from mild COVID-19, neutralizing antibody titers to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varied substantially at the time of discharge. In addition, neutralizing antibodies were not detected in 10 patients. Meaning Further research is needed to understand the implications of variable levels of SARS-CoV-2–specific neutralizing antibodies for protection against future infections with SARS-CoV-2.
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