How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function.
How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function.
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DOI：
10.1002/iub.1957
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发表时间：
2018-12
期刊：
影响因子：
4.6
通讯作者：
Alfonzo JD
中科院分区：
文献类型：
--
作者：
Paris Z;Alfonzo JD
生物体已经进化出不同的策略，将某些分子隔离在细胞的特定位置。这在具有广泛细胞内膜系统的真核生物中表现得最为明显。细胞内区室化在含有基因组的细胞器中尤为关键，由于这些细胞器具有细菌进化起源，它们仍然保留着蛋白质合成机制，这种机制与其进化起源的相似程度，要高于与它们作为内共生体加入的现存真核细胞的相似程度。尽管如此，很明显像线粒体这样含有基因组的细胞器并非孤立存在，许多分子能够从细胞质穿过线粒体膜。在这方面，转运核糖核酸（tRNA）及其修饰酶的输入被证明是最为重要的。在这篇综述中，我们讨论两个近期的例子，即在那些强制从细胞质输入所有tRNA的生物体中，通常在细胞质tRNA中发现的修饰是如何影响线粒体翻译的。我们认为，tRNA输入与修饰酶的区室化相结合，必定在细胞器的进化过程中发挥了关键作用。
Organisms have evolved different strategies to seclude certain molecules to specific locations of the cell. This is most pronounced in eukaryotes with their extensive intracellular membrane systems. Intracellular compartmentalization is particularly critical in genome containing organelles, which due to their bacterial evolutionary ancestry still maintain protein-synthesis machinery that resembles more their evolutionary origin than the extant eukaryotic cell they once joined as an endosymbiont. Despite this, it is clear that genome-containing organelles such as the mitochondria are not in isolation and many molecules make it across the mitochondrial membranes from the cytoplasm. In this realm the import of tRNAs and the enzymes that modify them prove most consequential. In this review we discuss two recent examples of how modifications typically found in cytoplasmic tRNAs affect mitochondrial translation in organisms that forcibly import all their tRNAs from the cytoplasm. In our view, the combination of tRNA import and the compartmentalization of modification enzymes must have played a critical role in the evolution of the organelle.
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影响因子：
5.5
作者：
Goto-Ito S;Ito T;Yokoyama S
通讯作者：
Yokoyama S
DOI：
10.1016/j.bbagrm.2017.11.007
发表时间：
2018-04
期刊：
Biochimica et biophysica acta. Gene regulatory mechanisms
影响因子：
--
作者：
Chatterjee K;Nostramo RT;Wan Y;Hopper AK
通讯作者：
Hopper AK
影响因子：
7.2
作者：
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通讯作者：
Marechal-Drouard, Laurence
影响因子：
4.8
作者：
Nakai, Y;Umeda, N;Kagamiyama, H
通讯作者：
Kagamiyama, H
影响因子：
4.1
作者：
Perche-Letuvee, Phanelie;Molle, Thibaut;Atta, Mohamed
通讯作者：
Atta, Mohamed