Cellular and molecular mechanisms of vascular lumen formation.

Cellular and molecular mechanisms of vascular lumen formation.
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DOI:
10.1016/j.devcel.2009.01.013
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发表时间:
2009-03
期刊:
影响因子:
11.8
通讯作者:
Davis GE
Davis GE
中科院分区:
生物学1区
文献类型:
--
作者:
Iruela-Arispe ML;Davis GE

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内皮细胞形成血管腔是血管新生过程中的一个关键步骤,发生在早期血管芽的侵入和生长期间。一旦管腔建立,毛细血管就迅速暴露于与血液流动相关的物理力,这些物理力与遗传信息一起调节内部血管直径的最终大小。在这里,我们回顾了最近的文献血管腔的形成,并比较它在其他上皮系统的管腔形成。我们还讨论了管腔直径的调节后,血管形态建成已经完成。
The formation of vascular lumens by endothelial cells is a critical step in the angiogenic process that occurs during invasion and growth of the incipient vascular sprout. Once a lumen is established, capillaries are rapidly exposed to the physical forces associated with the flow of blood which, together with genetic information, regulate the ultimate size of inner vessel diameter. Here we review the recent literature on vascular lumen formation and compare it to lumen formation in other epithelial systems. We also discuss the regulation of lumen diameter after vascular morphogenesis has been completed.
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