Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses.
Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses.
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DOI：
10.1002/advs.202100446
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Zhu D
中科院分区：
文献类型：
--
作者：
Zhang B;Su Y;Zhou J;Zheng Y;Zhu D
植入或损伤后的组织修复/再生涉及全面的生理过程，其中免疫反应在免疫细胞对组织损伤的早期反应中发挥关键作用，以实现组织修复。这些细胞分解细胞外基质，清除碎片，并分泌细胞因子以协调再生。然而，免疫反应也可能导致异常组织愈合或疤痕形成，如果没有很好地指导。本文首先介绍了损伤后的一般免疫反应，重点介绍了主要的免疫细胞，包括中性粒细胞，巨噬细胞和T细胞。接下来，讨论了各种植入物介导的免疫调节策略，通过物理，化学和生物学线索调节免疫反应。最后，提出了通过利用免疫调节来促进不同组织类型（如骨、软骨、血管和神经系统）的各种支架促进的再生。因此，本文介绍了生物材料和免疫调节方面的最新数据，以塑造专家的观点，激励研究人员走向新的方向，并推动未来战略的发展，重点是植入物引起的靶向、顺序和动态免疫调节。植入物介导的免疫调节是组织工程领域的一个新兴研究课题，是实现更好组织再生的一个新的有前途的方向。本文综述了免疫应答的机制及其对组织修复的影响、免疫调节策略、基于植入物的免疫调节在促进组织再生方面的最新体内应用，并讨论了当前面临的挑战和未来的前景。
Tissue repair/regeneration, after implantation or injury, involves comprehensive physiological processes wherein immune responses play a crucial role to enable tissue restoration, amidst the immune cells early‐stage response to tissue damages. These cells break down extracellular matrix, clear debris, and secret cytokines to orchestrate regeneration. However, the immune response can also lead to abnormal tissue healing or scar formation if not well directed. This review first introduces the general immune response post injury, with focus on the major immune cells including neutrophils, macrophages, and T cells. Next, a variety of implant‐mediated immunomodulation strategies to regulate immune response through physical, chemical, and biological cues are discussed. At last, various scaffold‐facilitated regenerations of different tissue types, such as, bone, cartilage, blood vessel, and nerve system, by harnessing the immunomodulation are presented. Therefore, the most recent data in biomaterials and immunomodulation is presented here in a bid to shape expert perspectives, inspire researchers to go in new directions, and drive development of future strategies focusing on targeted, sequential, and dynamic immunomodulation elicited by implants. Implant‐mediated immunomodulation represents an emerging research topic in the field of tissue engineering, and is a new promising direction to achieve better tissue regeneration. The underlying mechanism of immune response and its influence on tissue repair, immunomodulatory strategies, recent in vivo applications of implant‐based immunomodulation to improve tissue regeneration are summarized, and current challenges and future prospect are also discussed.
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