Muscle Eccentric Contractions Increase in Downhill and High-Grade Uphill Walking.
Muscle Eccentric Contractions Increase in Downhill and High-Grade Uphill Walking.
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DOI：
10.3389/fbioe.2020.573666
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发表时间：
2020
影响因子：
5.7
通讯作者：
Blemker SS
中科院分区：
文献类型：
--
作者：
Hu X;Pickle NT;Grabowski AM;Silverman AK;Blemker SS
Duchenne肌营养不良症是人类最严重和最常见的遗传病之一，在偏心收缩时，营养不良的肌肉容易受到机械应力的损伤。在平地上行走时的偏心收缩可能会导致腿部肌肉的退化。然而，人们对上坡/下坡步行对肌肉偏心收缩的影响知之甚少，上坡/下坡步行在患者的日常生活中经常遇到，并对生物力学提出了不同于水平步行的要求。通过重建一项已发表的健康受试者研究中的下坡(−9°、−6°和−3°)、上坡(+3°、+6°和+9°)和水平行走(0°)的动态肌肉骨骼模拟，量化和比较了35块下肢肌肉的负肌肉机械功，作为衡量偏心收缩的指标。结果表明，与水平步行相比，下坡总体上诱发更多的偏心收缩(−9°32%，−6°19%，−3°13%)。相反，上坡行走在低年级(+3°和+6°)导致类似于水平行走的偏心收缩，但在高年级(+9°)导致的偏心收缩比水平步行多17%。肌肉偏心收缩的变化在很大程度上是由坡道运动中关节负功和肌肉共激活的变化来预测的。由于肌肉偏心收缩在DMD的疾病进展中起着关键作用，这项研究为未来安全地改善DMD和其他类似疾病患者的康复策略和运动管理提供了重要的基线。
In Duchenne muscular dystrophy (DMD), one of the most severe and frequent genetic diseases in humans, dystrophic muscles are prone to damage caused by mechanical stresses during eccentric contractions. Eccentric contraction during walking on level ground likely contributes to the progression of degeneration in lower limb muscles. However, little is known about how the amount of muscle eccentric contractions is affected by uphill/downhill sloped walking, which is often encountered in patients’ daily lives and poses different biomechanical demands than level walking. By recreating the dynamic musculoskeletal simulations of downhill (−9°, −6°, and −3°), uphill (+3°, +6°, and +9°) and level walking (0°) from a published study of healthy participants, negative muscle mechanical work, as a measure of eccentric contraction, of 35 lower limb muscles was quantified and compared. Our results indicated that downhill walking overall induced more (32% at −9°, 19% at −6°, and 13% at −3°) eccentric contractions in lower limb muscles compared to level walking. In contrast, uphill walking led to eccentric contractions similar to level walking at low grades (+3° and +6°), but 17% more eccentric contraction at high grades (+9°). The changes of muscle eccentric contraction were largely predicted by the changes in both joint negative work and muscle coactivation in sloped walking. As muscle eccentric contractions play a critical role in the disease progression in DMD, this study provides an important baseline for future studies to safely improve rehabilitation strategies and exercise management for patients with DMD and other similar conditions.
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影响因子：
2.9
作者：
Arpan, Ishu;Forbes, Sean C.;Lott, Donovan J.;Senesac, Claudia R.;Daniels, Michael J.;Triplett, William T.;Deol, Jasjit K.;Sweeney, H. Lee;Walter, Glenn A.;Vandenborne, Krista
通讯作者：
Vandenborne, Krista
DOI：
10.1249/mss.0b013e31825703f0
发表时间：
2012-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Baltgalvis, Kristen A.;Call, Jarrod A.;Lowe, Dawn A.
通讯作者：
Lowe, Dawn A.
影响因子：
2.4
作者：
Alexander, Nathalie;Schwameder, Hermann
通讯作者：
Schwameder, Hermann
影响因子：
2.4
作者：
Alexander, Nathalie;Strutzenberger, Gerda;Schwameder, Hermann
通讯作者：
Schwameder, Hermann
双腿在上坡和下坡行走时的机械功。
影响因子：
2.4
作者：
Franz JR;Lyddon NE;Kram R
通讯作者：
Kram R