Unraveling the basic biology and clinical significance of the chlamydial plasmid.
Unraveling the basic biology and clinical significance of the chlamydial plasmid.
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DOI：
10.1084/jem.20112088
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发表时间：
2011-10-24
期刊：
影响因子：
--
通讯作者：
Rockey DD
中科院分区：
文献类型：
--
作者：
Rockey DD
新的证据表明，衣原体物种之间共享的保守质粒可能是了解和接种疫苗对抗这些病原菌的关键。衣原体质粒是一种高度保守、非接合性和非整合性的小DNA分子，在包括沙眼衣原体在内的许多衣原体种属中几乎普遍存在。最近在了解衣原体质粒参与宿主-微生物相互作用、疾病和免疫应答方面取得了重大进展。在小鼠模型系统和最近在非人灵长类动物中的研究表明，质粒缺陷型衣原体菌株可作为抗生殖器和眼部感染的减毒活疫苗。总的来说，这些研究为开发沙眼和性传播衣原体感染的疫苗开辟了新的研究途径。
New evidence indicates that the conserved plasmid shared among Chlamydial species may be key for understanding and vaccinating against these pathogenic bacteria. Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host–microbe interactions, disease, and immune responses. Work in mouse model systems and, very recently, in nonhuman primates demonstrates that plasmid-deficient chlamydial strains function as live attenuated vaccines against genital and ocular infections. Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections.
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影响因子：
3.8
作者：
STOREY, CC;LUSHER, M;RICHMOND, SJ
通讯作者：
RICHMOND, SJ
影响因子：
3.1
作者：
Burall, L. S.;Rodolakis, A.;Bavoil, P. M.
通讯作者：
Bavoil, P. M.
影响因子：
3.1
作者：
COMANDUCCI, M;MANETTI, R;RATTI, G
通讯作者：
RATTI, G
影响因子：
4.4
作者：
Seth-Smith, Helena M. B.;Harris, Simon R.;Clarke, Ian N.
通讯作者：
Clarke, Ian N.
影响因子：
2.8
作者：
Pickett, MA;Everson, JS;Clarke, IN
通讯作者：
Clarke, IN