Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.
Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.
复制标题
胃肠道Cajal间质细胞数学模型的应用现状。
DOI：
10.1002/wsbm.1507
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发表时间：
2021-03
影响因子：
3.1
通讯作者：
Du P
中科院分区：
文献类型：
--
作者：
Mah SA;Avci R;Cheng LK;Du P
Cajal间质细胞（ICC）在整个胃肠道（GI）中形成相互连接的网络。ICC作为起搏细胞，启动节律性生物电慢波，并在GI肌肉组织和神经之间起中介作用，这两者对GI运动至关重要。ICC数量和ICC网络完整性的破坏已被确定为许多临床挑战性GI疾病的关键病理生理机制。目前ICC的分析通常依赖于直接从切除的组织中获取的功能记录或基于标记ICC的图像的形态学分析，其中以关联方式而不是机械地研究结构-功能关系。另一方面，计算生理学在促进我们对健康和疾病中的一些生理系统的理解方面发挥了重要作用，并且GI领域的研究开始纳入ICC的几个数学模型。本次审查的主要目的是提出在GI电生理学的主要建模进展，以引入一个多尺度的框架，数学量化的ICC降解在细胞和组织尺度的功能后果。这些结果将为未来的研究人员在研究中利用建模技术提供信息。跨多个时空尺度的胃肠道Cajal间质细胞的数学模型。
The interstitial cells of Cajal (ICC) form interconnected networks throughout the gastrointestinal (GI) tract. ICC act as the pacemaker cells that initiate the rhythmic bioelectrical slow waves and intermediary between the GI musculature and nerves, both of which are critical to GI motility. Disruptions to the number of ICC and the integrity of ICC networks have been identified as a key pathophysiological mechanism in a number of clinically challenging GI disorders. The current analyses of ICC generally rely on either functional recordings taken directly from excised tissue or morphological analysis based on images of labeled ICC, where the structural-functional relationship is investigated in an associative manner rather than mechanistically. On the other hand, computational physiology has played a significant role in facilitating our understanding of a number of physiological systems in both health and disease, and investigations in the GI field are beginning to incorporate several mathematical models of the ICC. The main aim of this review is to present the major modeling advances in GI electrophysiology, in order to introduce a multi-scale framework for mathematically quantifying the functional consequences of ICC degradation at both cellular and tissue scales. The outcomes will inform future investigators utilizing modeling techniques in their studies. Mathematical models of the interstitial cells of Cajal in the gastrointestinal tract across multiple spatiotemporal scales.
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影响因子：
3.5
作者：
Du P;Hameed A;Angeli TR;Lahr C;Abell TL;Cheng LK;O'Grady G
通讯作者：
O'Grady G
影响因子：
3.9
作者：
Gao, Jerry;Du, Peng;Cheng, Leo K.
通讯作者：
Cheng, Leo K.
DOI：
10.1152/ajpgi.00528.2007
发表时间：
2008-04-01
影响因子：
4.5
作者：
Corrias, Alberto;Buist, Martin L.
通讯作者：
Buist, Martin L.
影响因子：
29.4
作者：
Grover M;Farrugia G;Lurken MS;Bernard CE;Faussone-Pellegrini MS;Smyrk TC;Parkman HP;Abell TL;Snape WJ;Hasler WL;Ünalp-Arida A;Nguyen L;Koch KL;Calles J;Lee L;Tonascia J;Hamilton FA;Pasricha PJ;NIDDK Gastroparesis Clinical Research Consortium
通讯作者：
NIDDK Gastroparesis Clinical Research Consortium
DOI：
10.1152/ajpgi.00074.2009
发表时间：
2009-06-01
影响因子：
4.5
作者：
Gomez-Pinilla, Pedro J.;Gibbons, Simon J.;Farrugia, Gianrico
通讯作者：
Farrugia, Gianrico