Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases.
Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases.
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DOI：
10.1021/acsbiomaterials.9b01255
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发表时间：
2020-02-10
影响因子：
5.8
通讯作者：
Jewell CM
中科院分区：
文献类型：
--
作者：
Yenkoidiok-Douti L;Jewell CM
Despite the success of vaccines in preventing many infectious diseases, effective vaccines against pathogens with ongoing challenges – such as HIV, malaria, and tuberculosis – remain unavailable. The emergence of new pathogen variants, the continued prevalence of existing pathogens, and the resurgence of yet other infectious agents motivate the need for new, interdisciplinary approaches to direct immune responses. Many current and candidate vaccines, for example, are poorly immunogenic, provide only transient protection, or create risks of regaining pathogenicity in certain immune-compromised conditions. Recent advances in biomaterials research are creating new potential to overcome these challenges through improved formulation, delivery, and control of immune signaling. At the same time, many of these materials systems – such as polymers, lipids, and self-assembly technologies – may achieve this goal while maintaining favorable safety profiles. This review highlights ways in which biomaterials can advance existing vaccines to safer, more efficacious technologies, and support new vaccines for pathogens that do not yet have vaccines. Biomaterials that have not yet been applied to vaccines for infectious disease are also discussed, and their potential in this area is highlighted
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影响因子：
9.7
作者：
Andorko JI;Hess KL;Pineault KG;Jewell CM
通讯作者：
Jewell CM
影响因子：
17.1
作者：
Abbink P;Larocca RA;Visitsunthorn K;Boyd M;De La Barrera RA;Gromowski GD;Kirilova M;Peterson R;Li Z;Nanayakkara O;Nityanandam R;Mercado NB;Borducchi EN;Chandrashekar A;Jetton D;Mojta S;Gandhi P;LeSuer J;Khatiwada S;Lewis MG;Modjarrad K;Jarman RG;Eckels KH;Thomas SJ;Michael NL;Barouch DH
通讯作者：
Barouch DH
影响因子：
64.8
作者：
Borducchi, Erica N.;Cabral, Crystal;Stephenson, Kathryn E.;Liu, Jinyan;Abbink, Peter;Ng'ang'a, David;Nkolola, Joseph P.;Brinkman, Amanda L.;Peter, Lauren;Lee, Benjamin C.;Jimenez, Jessica;Jetton, David;Mondesir, Jade;Mojta, Shanell;Chandrashekar, Abishek;Molloy, Katherine;Alter, Galit;Gerold, Jeffrey M.;Hill, Alison L.;Lewis, Mark G.;Pau, Maria G.;Schuitemaker, Hanneke;Hesselgesser, Joseph;Geleziunas, Romas;Kim, Jerome H.;Robb, Merlin L.;Michael, Nelson L.;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
影响因子：
7.8
作者：
Boraschi D;Italiani P
通讯作者：
Italiani P
影响因子：
5.5
作者：
Basu, Rupsa;Zhai, Lukai;Tumban, Ebenezer
通讯作者：
Tumban, Ebenezer