99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: darwinian medicine and the 'hygiene' or 'old friends' hypothesis.
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: darwinian medicine and the 'hygiene' or 'old friends' hypothesis.
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DOI：
10.1111/j.1365-2249.2010.04133.x
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发表时间：
2010-04
影响因子：
4.6
通讯作者：
Rook GA
中科院分区：
文献类型：
--
作者：
Rook GA
目前的“卫生假说”的综合表明，最近慢性炎症性疾病的增加至少部分归因于免疫失调，这是由于缺乏接触在免疫系统建立中发挥重要作用的微生物造成的。本文件为讨论下列建议提供了背景。这些生物体的基本作用是“进化依赖性”的一个例子。最相关的生物是那些与哺乳动物共同进化的生物，并且在旧石器时代就已经伴随着早期人类。最近进化的“儿童感染”不太可能进化出这种作用，最近的流行病学支持这一论点。这种机制与其他现代环境变化相互作用，也导致炎症反应增强[不适当的饮食，肥胖，心理压力，维生素D缺乏，污染（二恶英）等]。受影响的慢性炎症性疾病的范围可能比通常假设的更大[过敏，自身免疫，炎症性肠病，但也有血管疾病，某些癌症，抑郁/焦虑（当伴有炎性细胞因子升高时），可能还有神经退行性疾病和2型糖尿病]。
The current synthesis of the ‘hygiene hypothesis’ suggests that the recent increase in chronic inflammatory disorders is at least partly attributable to immunodysregulation resulting from lack of exposure to microorganisms that have evolved an essential role in the establishment of the immune system. This document provides a background for discussion of the following propositions. The essential role of these organisms is an example of ‘evolved dependence’. The most relevant organisms are those that co-evolved with mammals, and already accompanied early hominids in the Paleolithic. More recently evolved ‘childhood infections’ are not likely to have evolved this role, and recent epidemiology supports this contention. This mechanism is interacting with other modern environmental changes that also lead to enhanced inflammatory responses [inappropriate diet, obesity, psychological stress, vitamin D deficiency, pollution (dioxins), etc.]. The range of chronic inflammatory disorders that is affected is potentially larger than usually assumed [allergies, autoimmunity, inflammatory bowel disease, but also vascular disease, some cancers, depression/anxiety (when accompanied by raised inflammatory cytokines), and perhaps neurodegenerative disorders and type 2 diabetes].
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影响因子：
15.1
作者：
Fredericks, Carolyn A.;Drabant, Emily M.;Edge, Michael D.;Tillie, Jean M.;Hallmayer, Joachim;Ramel, Wiveka;Kuo, Janice R.;Mackey, Sean;Gross, James J.;Dhabhar, Firdaus S.
通讯作者：
Dhabhar, Firdaus S.
DOI：
10.1073/pnas.0707650104
发表时间：
2007-12-26
影响因子：
11.1
作者：
Hawks, John;Wang, Eric T.;Moyzis, Robert K.
通讯作者：
Moyzis, Robert K.
影响因子：
4.6
作者：
Ewald, P. W.
通讯作者：
Ewald, P. W.
DOI：
10.4269/ajtmh.2009.09-0237
发表时间：
2009-11-01
影响因子：
3.3
作者：
Blount, Daniel;Hooi, Doreen;Pritchard, David
通讯作者：
Pritchard, David
影响因子：
3.9
作者：
Ehses, Jan A.;Boeni-Schnetzler, Marianne;Donath, Marc Y.
通讯作者：
Donath, Marc Y.