Airway Epithelial Cell Junctions as Targets for Pathogens and Antimicrobial Therapy.
Airway Epithelial Cell Junctions as Targets for Pathogens and Antimicrobial Therapy.
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DOI：
10.3390/pharmaceutics14122619
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发表时间：
2022-11-27
期刊：
影响因子：
5.4
通讯作者：
Rezaee F
中科院分区：
文献类型：
--
作者：
Gao N;Rezaee F
上皮细胞之间的细胞间接触是由顶端连接复合体（AJC）建立和维持的。AJCs保存细胞极性，并建立上皮屏障，以抵御呼吸道中的病原体、吸入过敏原和环境颗粒。AJC由紧密连接（TJ）和粘附连接（AJs）组成，它们在维持气道屏障的完整性方面起着关键作用。新出现的证据表明，不同的微生物通过靶向TJ和AJ蛋白引起气道屏障功能障碍。本文综述了几种微生物（细菌和病毒）导致气道上皮细胞AJC破坏的病理生理机制。我们目前的最新进展，了解参与细胞连接的形成和调节的信号通路。我们还总结了潜在的化学抑制剂和药理学方法，以恢复气道上皮屏障的完整性。了解AJC-病原体相互作用和微生物靶向AJC并损害屏障功能的机制可能进一步有助于设计治疗这些感染的治疗创新。
Intercellular contacts between epithelial cells are established and maintained by the apical junctional complexes (AJCs). AJCs conserve cell polarity and build epithelial barriers to pathogens, inhaled allergens, and environmental particles in the respiratory tract. AJCs consist of tight junctions (TJs) and adherens junctions (AJs), which play a key role in maintaining the integrity of the airway barrier. Emerging evidence has shown that different microorganisms cause airway barrier dysfunction by targeting TJ and AJ proteins. This review discusses the pathophysiologic mechanisms by which several microorganisms (bacteria and viruses) lead to the disruption of AJCs in airway epithelial cells. We present recent progress in understanding signaling pathways involved in the formation and regulation of cell junctions. We also summarize the potential chemical inhibitors and pharmacological approaches to restore the integrity of the airway epithelial barrier. Understanding the AJCs–pathogen interactions and mechanisms by which microorganisms target the AJC and impair barrier function may further help design therapeutic innovations to treat these infections.
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