Determinants of nucleosome positioning.

Determinants of nucleosome positioning.
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核小体定位的决定因素。

DOI:
10.1038/nsmb.2506
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发表时间:
2013-03
影响因子:
16.8
通讯作者:
Segal, Eran
Segal, Eran
中科院分区:
生物学1区
文献类型:
--
作者:
Struhl, Kevin;Segal, Eran

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核小体定位对基因表达和大多数dna相关过程至关重要。在这里,我们回顾了已观察到的核小体定位的主要模式,并总结了目前对其潜在决定因素的理解。核小体的全基因组定位模式是由DNA序列、atp依赖性核小体重塑酶和转录因子(包括激活剂、起始前复合物组分和延长RNA聚合酶II)的组合决定的。这些决定因素相互影响,导致核小体的定位模式可能在基因之间和种群内的细胞之间有所不同,从而对基因表达产生影响。
Nucleosome positioning is critical for gene expression and most DNA-related processes. Here, we review the dominant patterns of nucleosome positioning that have been observed, and summarize current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP-dependent nucleosome remodeling enzymes, and transcription factors including activators, components of the preinitiation complex, and elongating RNA polymerase II. These determinants influence each other such that the resulting nucleosome positioning patterns are likely to differ among genes and among cells within a population, with consequent effects on gene expression.
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