Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users.
Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users.
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DOI：
10.1038/npp.2009.67
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发表时间：
2009-10
影响因子：
7.6
通讯作者：
Garavan, Hugh
中科院分区：
文献类型：
--
作者：
Hester, Robert;Nestor, Liam;Garavan, Hugh
药物滥用和其他精神疾病（如精神分裂症）与对错误的神经反应减弱有关，特别是在被认为对错误处理至关重要的前扣带皮层（ACC）。发现错误的能力下降与包括丧失洞察力、妄想和顽固行为在内的临床症状有关。16名活跃的慢性大麻使用者和16名对照参与者在事件相关的fMRI数据收集期间进行了Go/No-go反应抑制任务。该任务提供了抑制控制和错误感知的措施。大麻使用者的抑制性控制表现与对照组相当，但前者在佣金错误意识方面表现出显着缺陷。大麻使用者表现出监控自己行为的能力下降，这与前扣带和右脑岛的活动减少有关。此外，在吸食大麻的人群中，前扣带皮层和右脑岛区域的低活动水平的增加与错误意识率显著相关（但与对照组无关）。这些困难与先前关于慢性吸毒者认知控制和内感受意识监测的神经系统活性低下的报道一致，并突出了认知功能障碍和行为缺陷之间的潜在关系，这可能有助于维持药物滥用。
Drug abuse and other psychiatric conditions (e.g., schizophrenia) have been associated with a diminished neural response to errors, particularly in the anterior cingulate cortex (ACC) thought critical to error processing. A diminished capacity for detecting errors has been linked to clinical symptoms including the loss of insight, delusions and perseverative behaviour. Sixteen active chronic cannabis users and 16 control participants were administered a Go/No-go response inhibition task during event-related fMRI data collection. The task provides measures of inhibitory control and error awareness. Cannabis users’ inhibitory control performance was equivalent to that of the control group, but the former demonstrated a significant deficit in awareness of commission errors. Cannabis users demonstrated a diminished capacity for monitoring their behaviour that was associated with hypoactivity in the ACC and right insula. In addition, increased levels of hypoactivity in both the ACC and right insula regions were significantly correlated with error awareness rates in the cannabis group (but not controls). These difficulties are consistent with previous reports of hypoactivity in the neural systems underlying cognitive control and the monitoring of interoceptive awareness in chronic drug users, and highlight the potential relationship between cognitive dysfunction and behavioural deficits that have the potential to contribute to the maintenance of drug abuse.
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影响因子：
3.6
作者：
Liotti, M;Pliszka, SR;Woldorff, MG
通讯作者：
Woldorff, MG
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
7.6
作者：
Hester, Robert;Simoes-Franklin, Cristina;Garavan, Hugh
通讯作者：
Garavan, Hugh
DOI：
10.1016/s0926-6410(03)00144-7
发表时间：
2003-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Mostofsky, SH;Schafer, JGB;Pekar, JJ
通讯作者：
Pekar, JJ
影响因子：
16.2
作者：
Gray MA;Critchley HD
通讯作者：
Critchley HD