Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.
Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.
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DOI：
10.1093/cercor/bhac246
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发表时间：
2023-03-10
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影响因子：
--
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突触传递构成神经元之间沟通的主要模式。它在啮齿动物而非人类新皮质中得到了广泛的研究。我们使用神经外科切除的人类颞中回（MTG，布罗德曼区域 21）（分布式语言电路的一部分）来表征第 2 层和第 3 层锥体神经元之间的突触传递。我们发现局部连接与解剖同源体（时间关联区域）中的小鼠 2/3 层连接相当，但人类的突触连接更强、更可靠 3 倍（失败率分别为 0% 和 25%）。我们开发了一种量化棘突触特性的理论方法，表明人类树突棘的突触电导和电压变化比小鼠大 3-4 倍，导致人类单一连接中 NMDA 受体显着激活。该模型预测通过实验得到验证，表明 NMDA 受体激活会增加人类单一兴奋性突触后电位的振幅并延长其衰减，但在小鼠连接中则不然。由于 NMDA 依赖性周期性兴奋促进持续活动（支持工作记忆），因此我们的数据揭示了人类皮层微电路特性，这可能有助于 MTG 中的语言处理。
Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent but not human neocortex. We characterized synaptic transmission between pyramidal neurons in layers 2 and 3 using neurosurgically resected human middle temporal gyrus (MTG, Brodmann area 21), which is part of the distributed language circuitry. We find that local connectivity is comparable with mouse layer 2/3 connections in the anatomical homologue (temporal association area), but synaptic connections in human are 3-fold stronger and more reliable (0% vs 25% failure rates, respectively). We developed a theoretical approach to quantify properties of spinous synapses showing that synaptic conductance and voltage change in human dendritic spines are 3–4-folds larger compared with mouse, leading to significant NMDA receptor activation in human unitary connections. This model prediction was validated experimentally by showing that NMDA receptor activation increases the amplitude and prolongs decay of unitary excitatory postsynaptic potentials in human but not in mouse connections. Since NMDA-dependent recurrent excitation facilitates persistent activity (supporting working memory), our data uncovers cortical microcircuit properties in human that may contribute to language processing in MTG.
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影响因子：
3.5
作者：
Ecker A;Romani A;Sáray S;Káli S;Migliore M;Falck J;Lange S;Mercer A;Thomson AM;Muller E;Reimann MW;Ramaswamy S
通讯作者：
Ramaswamy S
DOI：
10.1023/a:1024134312173
发表时间：
2002-03-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
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作者：
Benavides-Piccione, R;Ballesteros-Yáñez, I;Yuste, R
通讯作者：
Yuste, R
影响因子：
3.7
作者：
Barros-Zulaica, Natali;Rahmon, John;Ramaswamy, Srikanth
通讯作者：
Ramaswamy, Srikanth
DOI：
10.1093/cercor/bhab349
发表时间：
2022-05-30
期刊：
Cerebral cortex (New York, N.Y. : 1991)
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--
作者：
通讯作者：
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影响因子：
64.8
作者：
Brown, Solange P.;Hestrin, Shaul
通讯作者：
Hestrin, Shaul