Neural intrinsic connectivity networks associated with risk aversion in old age.
Neural intrinsic connectivity networks associated with risk aversion in old age.
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DOI：
10.1016/j.bbr.2011.10.026
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发表时间：
2012-02-01
影响因子：
2.7
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
--
作者：
Han, S. Duke;Boyle, Patricia A.;Arfanakis, Konstantinos;Fleischman, Debra A.;Yu, Lei;Edmonds, Emily C.;Bennett, David A.
风险规避与真实的世界的几个重要结果有关。虽然神经生物学相关的风险厌恶已经在年轻人中进行了研究，但对老年人风险厌恶的神经生物学相关性知之甚少。静息状态下的功能性MRI数据收集了134名非痴呆参与者的拉什记忆和衰老项目，一个以社区为基础的队列研究老化。风险厌恶是使用一系列标准问题来衡量的，在这些问题中，参与者被要求在一定的金钱支付（15美元）与赌博之间做出选择，在赌博中，他们可以获得超过15美元或一无所获，潜在的收益因问题而异。被确定为“高”（n=27）和“低”（n=27）的风险厌恶的参与者进行相应的分组。使用前扣带皮层中感兴趣的球形种子区域，在双侧额叶、前扣带和后扣带、丘脑、基底神经节、颞叶、顶叶和丘脑区域中观察到体素功能连接网络相似性。观察到功能连接的差异，风险厌恶程度低的人与上级、中间和内侧额叶区域以及小脑、顶叶、枕叶和颞叶下部区域的集群连接更强。那些高风险厌恶度的人与下额叶和眶额叶、海马旁区和颞叶区，以及丘脑、顶叶、中央前回、中央后回和中颞区的集群有更大的联系。功能连接模式的相似性和差异可能反映了特定大脑区域在老年人主动处理风险中作为网络的历史招募。
Risk aversion is associated with several important real world outcomes. Although the neurobiological correlates of risk aversion have been studied in young persons, little is known of the neurobiological correlates of risk aversion among older persons. Resting-state functional MRI data were collected on 134 non-demented participants of the Rush Memory and Aging Project, a community-based cohort study of aging. Risk aversion was measured using a series of standard questions in which participants were asked to choose between a certain monetary payment ($15) versus a gamble in which they could gain more than $15 or gain nothing, with potential gains varied across questions. Participants determined to be “high” (n=27) and “low” (n=27) in risk aversion were grouped accordingly. Using a spherical seed region of interest in the anterior cingulate cortex, voxel-wise functional connectivity network similarities were observed in bilateral frontal, anterior and posterior cingulate, insula, basal ganglia, temporal, parietal, and thalamic regions. Differences in functional connectivity were observed such that those low in risk aversion had greater connectivity to clusters in the superior, middle, and medial frontal regions, as well as cerebellar, parietal, occipital, and inferior temporal regions. Those high in risk aversion had greater connectivity to clusters in the inferior and orbital frontal, parahippocampal, and insula regions, as well as thalamic, parietal, precentral gyrus, postcentral gyrus, and middle temporal regions. Similarities and differences in functional connectivity patterns may reflect the historical recruitment of specific brain regions as a network in the active processing of risk in older adults.
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影响因子：
4.1
作者：
Boyle PA;Yu L;Buchman AS;Laibson DI;Bennett DA
通讯作者：
Bennett DA
影响因子：
3.3
作者：
Glover, GH;Thomason, ME
通讯作者：
Thomason, ME
影响因子：
25
作者：
O'Doherty, J;Kringelbach, ML;Andrews, C
通讯作者：
Andrews, C
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
3.7
作者：
Ostrowsky, K;Magnin, M;Mauguière, F
通讯作者：
Mauguière, F