A frog's view of EphrinB signaling.
A frog's view of EphrinB signaling.
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DOI：
10.1002/dvg.23002
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Daar IO
中科院分区：
文献类型：
--
作者：
Hwang YS;Daar IO
细胞-细胞和细胞-基质粘附对于发育过程中组织模式的正确形成和维持是必不可少的，并且这些过程的失调可导致癌细胞的侵袭和转移。细胞表面粘附和信号分子是正常发育和癌症进展的关键参与者。一组细胞表面蛋白，Eph受体酪氨酸激酶和它们的膜结合配体肝配蛋白，是这些过程的重要调节剂。在胚胎发育过程中，Eph/ephrin信号系统参与细胞-细胞接触事件，导致细胞分选和受体和配体携带细胞之间的边界形成。当展示膜结合配体或受体的迁移细胞与携带同源配偶体的细胞接触时，反应可能是粘附或排斥，最终导致这些细胞的正确定位。在癌症进展期间，这些受体/配体对之间的信号传导通常失调，导致侵袭和转移增加。为了深入了解介导Eph受体和ephrin信号传导的途径，我们依赖于一个非常容易处理的系统，即蛙爪蟾。该模型系统已被证明是非常通用的，并代表了一个相对快速和可操作的系统，以探索信号事件和受这些信号影响的体内过程。
Cell–cell and cell–substrate adhesion are essential to the proper formation and maintenance of tissue patterns during development, and deregulation of these processes can lead to invasion and metastasis of cancer cells. Cell surface adhesion and signaling molecules are key players in both normal development and cancer progression. One set of cell surface proteins, the Eph receptor tyrosine kinases and their membrane-bound ligands, ephrins, are significant regulators of these processes. During embryonic development, the Eph/ephrin signaling system is involved in cell–cell contact events that result in cell sorting and boundary formation between receptor and ligand bearing cells. When migrating cells that display the membrane bound ligands or receptors come in contact with cells bearing the cognate partner, the response may be adhesion or repulsion, ultimately leading to the proper positioning of these cells. During cancer progression, the signaling between these receptor/ligand pairs is often deregulated, leading to increased invasion and metastasis. To gain mechanistic insight into the pathways that mediate Eph receptor and ephrin signaling we have relied upon a very tractable system, the frog Xenopus. This model system has proven to be extremely versatile, and represents a relatively quick and manipulable system to explore signaling events and the in vivo processes affected by these signals.
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