Low bone mass is associated with carotid calcification plaque in Chinese postmenopausal women: the Chongqing osteoporosis study
Low bone mass is associated with carotid calcification plaque in Chinese postmenopausal women: the Chongqing osteoporosis study
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中国绝经后妇女低骨量与颈动脉钙化斑块相关：重庆骨质疏松症研究
DOI：
10.1080/13697137.2019.1671818
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发表时间：
2020-05
期刊：
影响因子：
2.8
通讯作者：
Rui Zhou
中科院分区：
文献类型：
--
作者：
Dong Liu;Le Chen;Shuyang Dong;Hai Yang;Ling Li;Juan Liu;Huadong Zhou;Rui Zhou
背景：本研究的目的是探讨中国绝经后妇女低骨量与颈动脉钙化斑块风险之间的关系。方法：我们进行了一项为期5年的前瞻性研究。双能X线骨密度仪（DXA）测量骨密度（BMD）。使用64排多探测器扫描仪进行颈动脉计算机断层扫描血管造影（CTA），以评估基线和随访期间的颈动脉斑块。考克斯比例风险分析被用来评估BMD和颈动脉钙化plaics.Results的风险的关联：488名妇女持续前瞻性颈动脉斑块在随访期间。有颈动脉钙化斑块的女性比颈动脉无钙化斑块的女性骨密度低。校正潜在混杂因素后，BMD、年龄、绝经年限、血浆骨保护素和脂联素水平、高血压、糖尿病和高脂血症与颈动脉钙化斑块风险增加独立相关。对于颈动脉钙化斑块，一个显着的负相关，表明BMD和斑块之间，和一个显着的正相关，表明之间的骨丢失和plaics.Conclusions：这项研究表明，低BMD和增加丢失率的BMD与高风险的颈动脉钙化斑块在中国绝经后妇女。
Background:The aim of this study was to examine the relationship between low bone mass and the risk of carotid calcification plaques in Chinese postmenopausal women.Methods:We conducted a 5 years prospective study. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) scanning. Carotid computed tomography angiography (CTA) was conducted using a 64-multidetector row scanner to assess carotid arterial plaque at baseline and during follow-up. Cox proportional hazards analysis was used to evaluate the association of BMD and risk of carotid calcification plaques.Results:Four hundred and eighty-eight women sustained prospective carotid plaques during the follow-up. Women with carotid calcification plaques had low BMD than those with carotid non-calcification plaques. After adjustment for potential confounders, BMD, age, years since menopause, levels of plasma osteoprotegerin and adiponectin, hypertension, diabetes mellitus and hyperlipidemia were independently associated with increased risk of carotid calcification plaques. For carotid calcification plaques, a significant inverse correlation was indicated between BMD and the plaques, and a significant positive correlation was indicated between bone loss and plaques.Conclusions:This study suggested that lower BMD and increased loss rate of BMD were associated with a higher risk of carotid calcification plaques in Chinese postmenopausal women.
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影响因子：
4
作者：
Wu, J.;Xu, L.;Li, L.
通讯作者：
Li, L.
影响因子：
2.2
作者：
J. Jürimäe;K. Rembel;T. Jürimäe;M. Rehand
通讯作者：
J. Jürimäe;K. Rembel;T. Jürimäe;M. Rehand
影响因子：
2.7
作者：
A. Colombini;G. Lombardi;E. Galliera;G. Dogliotti;P. Randelli;Alexander Meerssemann;Giuseppe Mineo;P. Cabitza;M. Corsi
通讯作者：
A. Colombini;G. Lombardi;E. Galliera;G. Dogliotti;P. Randelli;Alexander Meerssemann;Giuseppe Mineo;P. Cabitza;M. Corsi
影响因子：
1.6
作者：
Tian L;Yang R;Wei L;Liu J;Yang Y;Shao F;Ma W;Li T;Wang Y;Guo T
通讯作者：
Guo T
DOI：
10.1056/nejmoa1809798
发表时间：
2019-02-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ridker PM;Everett BM;Pradhan A;MacFadyen JG;Solomon DH;Zaharris E;Mam V;Hasan A;Rosenberg Y;Iturriaga E;Gupta M;Tsigoulis M;Verma S;Clearfield M;Libby P;Goldhaber SZ;Seagle R;Ofori C;Saklayen M;Butman S;Singh N;Le May M;Bertrand O;Johnston J;Paynter NP;Glynn RJ;CIRT Investigators
通讯作者：
CIRT Investigators