Respiratory plasticity following spinal cord injury: perspectives from mouse to man.
Respiratory plasticity following spinal cord injury: perspectives from mouse to man.
复制标题
脊髓损伤后的呼吸可塑性：从小鼠到人类的视角。
DOI：
10.4103/1673-5374.335839
复制
发表时间：
2022-10
影响因子：
6.1
通讯作者：
Lane, Michael
中科院分区：
文献类型：
--
作者：
Locke, Katherine;Randelman, Margo;Hoh, Daniel;Zholudeva, Lyandysha;Lane, Michael
动物模型呼吸可塑性的研究已经持续了几十年。在实验台上，研究人员使用了一系列技术，旨在利用中枢神经系统的可塑性来恢复脊髓损伤后的呼吸。这一研究领域与临床高度相关。颈脊髓损伤患者在脊髓水平C3-C5的膈运动神经元池水平或以上，通常有明显的呼吸障碍，可能需要辅助通气。那些依赖呼吸机的人患呼吸机相关合并症的风险增加，预期寿命大大缩短。动物模型呼吸可塑性的临床前研究为临床试验奠定了基础。尽管在动物模型中对这种损伤进行了广泛的研究，但相对较少的治疗方法突破了临床前障碍。本综述的三个目标是定义脊髓损伤后呼吸功能的可塑性，讨论研究中使用的脊髓损伤的可塑性模型，并探讨从临床前研究到临床研究的转变。通过研究呼吸可塑性研究的当前目标，我们希望阐明临床前工作，从而影响未来的临床研究和脊髓损伤治疗的进展。
The study of respiratory plasticity in animal models spans decades. At the bench, researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord injury. This field of research is highly clinically relevant. People living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3–C5 typically have significant impairments in breathing which may require assisted ventilation. Those who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life expectancy. Pre-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical trials. Despite how widely researched this injury is in animal models, relatively few treatments have broken through the preclinical barrier. The three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury, discuss plasticity models of spinal cord injury used in research, and explore the shift from preclinical to clinical research. By investigating current targets of respiratory plasticity research, we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.
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