Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia.
Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia.
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DOI：
10.2337/db09-0713
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发表时间：
2009-12
期刊：
影响因子：
7.7
通讯作者：
Pedersen BK
中科院分区：
文献类型：
--
作者：
Hojman P;Pedersen M;Nielsen AR;Krogh-Madsen R;Yfanti C;Akerstrom T;Nielsen S;Pedersen BK
成纤维细胞生长因子-21（FGF-21）是一种有效的代谢调节剂，在动物模型中已显示其改善葡萄糖代谢和胰岛素敏感性。最近，FGF-21被证明是表达和分泌的小鼠肌肉细胞响应胰岛素刺激。我们研究了高胰岛素-正葡萄糖钳夹过程中年轻健康男性急性胰岛素刺激后肌肉FGF-21表达和血浆FGF-21。此外，我们研究了有或没有胰岛素抵抗和慢性胰岛素升高的人的全身水平和肌肉FGF-21表达。在胰岛素输注前，年轻健康男性中几乎检测不到FGF-21。在高胰岛素-正葡萄糖钳夹过程中输注胰岛素3或4小时后，肌肉FGF-21表达显著增加。血浆FGF-21遵循相同的模式。在慢性胰岛素升高的个体中，肌肉FGF-21表达与男性高胰岛素血症相关，但与女性无关。在血浆中，高胰岛素血症和空腹血糖与血浆FGF-21呈正相关，而血浆FGF-21与HDL胆固醇呈负相关。在慢性高胰岛素血症的个体中没有发现肌肉和血浆FGF-21之间的关联。FGF-21在人骨骼肌中响应于胰岛素刺激而表达，表明FGF-21是胰岛素调节的肌因子。作为支持，我们发现慢性高胰岛素血症和FGF-21水平之间存在关联。
Fibroblast growth factor-21 (FGF-21) is a potent metabolic regulator, which in animal models has been shown to improve glucose metabolism and insulin sensitivity. Recently, FGF-21 was shown to be expressed and secreted from murine muscle cells in response to insulin stimulation. We studied muscular FGF-21 expression and plasma FGF-21 after acute insulin stimulation in young healthy men during a hyperinsulinemic- euglycemic clamp. Furthermore, we investigated systemic levels and muscle FGF-21 expression in humans with or without insulin resistance and chronic elevated insulin. FGF-21 was barely detectable in young healthy men before insulin infusion. After 3 or 4 h of insulin infusion during a hyperinsulinemic-euglycemic clamp, muscular FGF-21 expression increased significantly. Plasma FGF-21 followed the same pattern. In individuals with chronic elevated insulin, muscular FGF-21 expression was associated with hyperinsulinemia in men but not in women. In plasma, hyperinsulinemia and fasting glucose were positively associated with plasma FGF-21 while plasma FGF-21 correlated negatively with HDL cholesterol. No associations between muscle and plasma FGF-21 were found in the individuals with chronic hyperinsulinemia. FGF-21 is expressed in human skeletal muscle in response to insulin stimulation, suggesting that FGF-21 is an insulin-regulated myokine. In support, we found an association between chronic hyperinsulinemia and levels of FGF-21.
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DOI：
10.1016/j.bbrc.2007.06.068
发表时间：
2007-08-24
影响因子：
3.1
作者：
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影响因子：
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发表时间：
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影响因子：
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