Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility.
Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility.
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DOI：
10.1038/s41591-021-01383-w
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发表时间：
2021-08
期刊：
影响因子：
82.9
通讯作者：
Hayden, Mary K.
中科院分区：
文献类型：
--
作者：
Proctor, Diana M.;Dangana, Thelma;Sexton, D. Joseph;Fukuda, Christine;Yelin, Rachel D.;Stanley, Mary;Bell, Pamela B.;Baskaran, Sangeetha;Deming, Clay;Chen, Qiong;Conlan, Sean;Park, Morgan;Welsh, Rory M.;Vallabhaneni, Snigdha;Chiller, Tom;Forsberg, Kaitlin;Black, Stephanie R.;Pacilli, Massimo;Kong, Heidi H.;Lin, Michael Y.;Schoeny, Michael E.;Litvintseva, Anastasia P.;Segre, Julia A.;Hayden, Mary K.
金黄色念珠菌是一种高度关注的真菌病原体，因为它能够引起医疗保健相关的感染和暴发，它对抗菌剂和消毒剂的耐药性，以及它在人体皮肤和无生命环境中的持久性。为了给监测和未来的缓解策略提供信息，我们定义了皮肤定植的程度，并探索了与金黄色葡萄球菌定植相关的微生物群。我们在2019年1月至4月的三个时间点收集了57名居民(每人最多10个身体部位)的拭子样本和临床数据，这些居民是地方性金黄色葡萄球菌和常规洗必泰(CHG)洗澡的具有呼吸机能力的熟练护理设施的居民。结合微生物基因组学和流行病学数据，揭示了奥氏隐匿性弧菌在多个身体部位的定植，通常不是筛查的目标。高浓度的CHG与抑制金黄色葡萄球菌的生长有关，但与对共生微生物的有害扰动无关。通过对人类霉菌群动态的模拟，可以洞察到皮肤真菌群落的潜在变化是获得和持续感染金黄色葡萄球菌的一个可能的可改变的风险因素。未能发现广泛的、不同的奥里斯定殖区，可能会降低针对被殖民居民的感染预防措施的有效性，突显出普遍策略的重要性，以减少金黄色葡萄球菌的传播。
Candida auris is a fungal pathogen of high concern due to its ability to cause healthcare-associated infections and outbreaks, its resistance to antimicrobials and disinfectants and its persistence on human skin and in the inanimate environment. To inform surveillance and future mitigation strategies, we defined the extent of skin colonization and explored the microbiome associated with C. auris colonization. We collected swab specimens and clinical data at three times points between January and April 2019 from 57 residents (up to ten body sites each) of a ventilator-capable skilled nursing facility with endemic C. auris and routine chlorhexidine gluconate (CHG) bathing. Integrating microbial-genomic and epidemiologic data revealed occult C. auris colonization of multiple body sites not targeted commonly for screening. High concentrations of CHG were associated with suppression of C. auris growth but not with deleterious perturbation of commensal microbes. Modeling human mycobiome dynamics provided insight into underlying alterations to the skin fungal community as a possible modifiable risk factor for acquisition and persistence of C. auris. Failure to detect the extensive, disparate niches of C. auris colonization may reduce the effectiveness of infection-prevention measures that target colonized residents, highlighting the importance of universal strate- gies to reduce C. auris transmission.
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影响因子：
4.5
作者：
Popovich KJ;Lyles R;Hayes R;Hota B;Trick W;Weinstein RA;Hayden MK
通讯作者：
Hayden MK
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J
DOI：
10.1073/pnas.1502875112
发表时间：
2015-09-01
影响因子：
11.1
作者：
DiGiulio, Daniel B.;Callahan, Benjamin J.;Relman, David A.
通讯作者：
Relman, David A.
DOI：
10.1016/j.jamcollsurg.2007.12.054
发表时间：
2008-08-01
影响因子：
5.2
作者：
Edmiston, Charles E., Jr.;Krepel, Candace J.;Towne, Jonathan B.
通讯作者：
Towne, Jonathan B.