The septin cytoskeleton: Heteromer composition defines filament function.

The septin cytoskeleton: Heteromer composition defines filament function.
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DOI:
10.1083/jcb.202302010
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发表时间:
2023-03-06
期刊:
The Journal of cell biology
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Güler和Mostowy讨论了Gladfelter实验室和Mavrakis实验室的文章,分别讨论了septins组织成细丝如何指导它们在酵母和人类中的功能。隔膜蛋白是一个进化上保守的蛋白质家族,其成员形成异源寡聚复合物,组装成细丝和更高级的结构。在这个问题上,Martins et al.(2022. https://doi.org/10.1083/jcb.202203016)和Cannon等人(2023. org/10.1083/jcb. 202204063)报道了异聚体组成影响Septin细丝在酵母和人细胞中的生理作用。
Güler and Mostowy discuss articles from the Gladfelter lab and from the Mavrakis lab on how the organization of septins into filaments directs their function in yeast and humans, respectively. Septins are an evolutionarily conserved protein family whose members form hetero-oligomeric complexes that assemble into filaments and higher-order structures. In this issue, Martins et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202203016) and Cannon et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204063) report that heteromer composition impacts the physiological role of septin filaments in yeast and human cells.
DOI: 10.1083/jcb.202203016
发表时间: 2023-03-06
期刊: The Journal of cell biology
影响因子: --
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通讯作者: --
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