Septins From Protists to People.
Septins From Protists to People.
复制标题
DOI：
10.3389/fcell.2021.824850
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Momany M
中科院分区：
文献类型：
--
作者：
Shuman B;Momany M
Septin gtp酶形成非极性异聚物，在细胞分裂和其他细胞过程中起重要作用。形成异聚物的能力似乎对许多septin功能至关重要，并且是许多septin结构域高度保守的主要驱动因素。九肽可分为五个同源基团。基团1-4的成员相互作用形成异聚物，被称为“核心septin”。到目前为止，所有真菌和动物中都存在代表性的核心片段，并且在群内保守的异聚物中显示出与单体位置的位置同源性。相比之下，第5基团的成员不是标准杂聚物的一部分，似乎只与核心聚类短暂地相互作用，如果有的话。第5群septin呈点状分布，已在特定真菌、纤毛虫、绿藻和褐藻中发现。在这篇综述中，我们比较了跨越生命树的九种模式生物（智人、黑腹果蝇、曼氏血吸虫、秀丽隐杆线虫、酿酒酵母菌、灰曲霉、米氏大孔菌、嗜热四膜虫和莱茵衣单胞菌）的毒素。我们专注于分类，进化关系，保守基序，单体之间的界面，以及异聚物的位置同源性。了解跨界的septin之间的关系可以让我们对它们的功能有新的认识。
Septin GTPases form nonpolar heteropolymers that play important roles in cytokinesis and other cellular processes. The ability to form heteropolymers appears to be critical to many septin functions and to have been a major driver of the high conservation of many septin domains. Septins fall into five orthologous groups. Members of Groups 1–4 interact with each other to form heterooligomers and are known as the “core septins.” Representative core septins are present in all fungi and animals so far examined and show positional orthology with monomer location in the heteropolymer conserved within groups. In contrast, members of Group 5 are not part of canonical heteropolymers and appear to interact only transiently, if at all, with core septins. Group 5 septins have a spotty distribution, having been identified in specific fungi, ciliates, chlorophyte algae, and brown algae. In this review we compare the septins from nine well-studied model organisms that span the tree of life (Homo sapiens, Drosophila melanogaster, Schistosoma mansoni, Caenorhabditis elegans, Saccharomyces cerevisiae, Aspergillus nidulans, Magnaporthe oryzae, Tetrahymena thermophila, and Chlamydomonas reinhardtii). We focus on classification, evolutionary relationships, conserved motifs, interfaces between monomers, and positional orthology within heteropolymers. Understanding the relationships of septins across kingdoms can give new insight into their functions.
登录
查看更多内容
影响因子：
3.4
作者：
Pan F;Malmberg RL;Momany M
通讯作者：
Momany M
影响因子：
3.7
作者：
Hernández-Rodríguez Y;Masuo S;Johnson D;Orlando R;Smith A;Couto-Rodriguez M;Momany M
通讯作者：
Momany M
影响因子：
11.4
作者：
John, Corinne M.;Hite, Richard K.;Steinmetz, Michel O.
通讯作者：
Steinmetz, Michel O.
影响因子：
5.6
作者：
Bertin A;McMurray MA;Thai L;Garcia G 3rd;Votin V;Grob P;Allyn T;Thorner J;Nogales E
通讯作者：
Nogales E
影响因子：
7.8
作者：
Bai, Xiaobo;Bowen, Jonathan R.;Spiliotis, Elias T.
通讯作者：
Spiliotis, Elias T.