Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications.
Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications.
复制标题
产前并发症的女性，每个三个月循环的亲吻蛋白水平的变化。
DOI：
10.1210/clinem/dgab617
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发表时间：
2022-01-01
期刊：
影响因子：
--
通讯作者：
Dhillo WS
中科院分区：
文献类型：
--
作者：
Abbara A;Al-Memar M;Phylactou M;Daniels E;Patel B;Eng PC;Nadir R;Izzi-Engbeaya C;Clarke SA;Mills EG;Hunjan T;Pacuszka E;Yang L;Bech P;Tan T;Comninos AN;Kelsey TW;Kyriacou C;Fourie H;Bourne T;Dhillo WS
Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications. We aimed to assess whether kisspeptin levels are altered in women with antenatal complications. Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed. Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P < 0.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P = 0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P = 0.014) and lower in those with GDM (P = 0.020), but not significantly on multivariable analysis. We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.
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影响因子：
4.3
作者：
Dahlstrom, Berit;Romundstad, Pal;Eskild, Anne
通讯作者：
Eskild, Anne
DOI：
10.1530/joe-12-0091
发表时间：
2012-07
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Cartwright JE;Williams PJ
通讯作者：
Williams PJ
影响因子：
3.7
作者：
Francis VA;Abera AB;Matjila M;Millar RP;Katz AA
通讯作者：
Katz AA
影响因子：
8.2
作者：
Hiden, Ursula;Bilban, Martin;Desoye, Gernot
通讯作者：
Desoye, Gernot
影响因子：
2.6
作者：
Kapustin, R. V.;Drobintseva, A. O.;Kvetnoy, I. M.
通讯作者：
Kvetnoy, I. M.