Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation.
Polymorphisms in Fatty Acid Desaturase (FADS) Gene Cluster: Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty Acids (PUFA) Supplementation.
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DOI：
10.3390/genes4030485
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发表时间：
2013-09-10
期刊：
影响因子：
3.5
通讯作者：
Vohl MC
中科院分区：
文献类型：
--
作者：
Cormier H;Rudkowska I;Thifault E;Lemieux S;Couture P;Vohl MC
去饱和酶活性的变化与胰岛素敏感性相关，并且可能与 2 型糖尿病 (T2DM) 相关。脂肪酸去饱和酶 (FADS) 基因簇中的多态性 (SNP) 与胰岛素敏感性稳态模型评估 (HOMA-IS) 和血清脂肪酸组成相关。目的：研究 FADS 基因簇中常见的遗传变异是否影响补充 6 周 n-3 多不饱和脂肪酸 (PUFA) 后的空腹血糖 (FG) 和空腹胰岛素 (FI) 反应。方法：210 名受试者完成了 2 周的磨合期，随后为期 6 周补充 5 克/天的鱼油（提供 1.9 克–2.2 克 EPA + 1.1 克 DHA）。对 FADS 基因簇的 18 个 SNP 进行了基因分型，涵盖了所有常见遗传变异的 90%（次要等位基因频率≥ 0.03）。结果：在根据基线、年龄、性别和 BMI 调整 FG 水平的模型中，补充 n-3 PUFA 后，rs482548 (FADS2) 次要等位基因的携带者血浆 FG 水平增加。 rs482548 观察到显着的基因型*补充剂相互作用对 FG 水平的影响 (p = 0.008)。对于 FI 水平，观察到一个 SNP (rs174456) 的基因型效应。对于 HOMA-IS，观察到 rs7394871、rs174602、rs174570、rs7482316 和 rs482548 的几种基因型*补充相互作用效应（分别为 p = 0.03、p = 0.01、p = 0.03、p = 0.05 和 p = 0.07）。结论：结果表明，FADS 基因簇中的 SNP 可能会响应 n-3 PUFA 补充而调节血浆 FG、FI 和 HOMA-IS 水平。
Changes in desaturase activity are associated with insulin sensitivity and may be associated with type 2 diabetes mellitus (T2DM). Polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster have been associated with the homeostasis model assessment of insulin sensitivity (HOMA-IS) and serum fatty acid composition. Objective: To investigate whether common genetic variations in the FADS gene cluster influence fasting glucose (FG) and fasting insulin (FI) responses following a 6-week n-3 polyunsaturated fatty acids (PUFA) supplementation. Methods: 210 subjects completed a 2-week run-in period followed by a 6-week supplementation with 5 g/d of fish oil (providing 1.9 g–2.2 g of EPA + 1.1 g of DHA). Genotyping of 18 SNPs of the FADS gene cluster covering 90% of all common genetic variations (minor allele frequency ≥ 0.03) was performed. Results: Carriers of the minor allele for rs482548 (FADS2) had increased plasma FG levels after the n-3 PUFA supplementation in a model adjusted for FG levels at baseline, age, sex, and BMI. A significant genotype*supplementation interaction effect on FG levels was observed for rs482548 (p = 0.008). For FI levels, a genotype effect was observed with one SNP (rs174456). For HOMA-IS, several genotype*supplementation interaction effects were observed for rs7394871, rs174602, rs174570, rs7482316 and rs482548 (p = 0.03, p = 0.01, p = 0.03, p = 0.05 and p = 0.07; respectively). Conclusion: Results suggest that SNPs in the FADS gene cluster may modulate plasma FG, FI and HOMA-IS levels in response to n-3 PUFA supplementation.
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影响因子：
14.9
作者：
Cartegni, L;Wang, JH;Krainer, AR
通讯作者：
Krainer, AR
影响因子：
4.5
作者：
Kim OY;Lim HH;Yang LI;Chae JS;Lee JH
通讯作者：
Lee JH
DOI：
10.1016/0005-2736(82)90318-2
发表时间：
1982-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
GINSBERG, BH;JABOUR, J;SPECTOR, AA
通讯作者：
SPECTOR, AA
DOI：
10.1016/0006-291x(81)91682-x
发表时间：
1981-01-01
影响因子：
3.1
作者：
GRUNFELD, C;BAIRD, KL;KAHN, CR
通讯作者：
KAHN, CR
影响因子：
5.9
作者：
Cormier H;Rudkowska I;Paradis AM;Thifault E;Garneau V;Lemieux S;Couture P;Vohl MC
通讯作者：
Vohl MC