Expanding horizons: ciliary proteins reach beyond cilia.
Expanding horizons: ciliary proteins reach beyond cilia.
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DOI：
10.1146/annurev-genet-111212-133243
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发表时间：
2013
影响因子：
11.1
通讯作者：
Sun Z
中科院分区：
文献类型：
--
作者：
Yuan S;Sun Z
曾经默默无闻的纤毛在过去十年中开始成为人们关注的焦点。现在很清楚，除了通过运动纤毛产生运动之外，运动纤毛和不动纤毛都充当细胞的信号平台。通过运动和感觉功能，纤毛在发育、体内平衡和疾病中发挥着关键作用。迄今为止，纤毛蛋白质组包含 1,000 多种不同的蛋白质，人类遗传学正在以越来越快的速度识别新的纤毛病基因。尽管为不动的纤毛分配功能不久前还是一个挑战，但与纤毛相关的无数信号通路、蛋白质和生物过程现在造成了一个新的障碍：如何将所有这些相互作用提炼成特定的主题和机制，以解释细胞器如何维持有机体稳态。在此，我们回顾了纤毛生物学的基础知识、与纤毛相关的新功能以及纤毛遗传学的最新进展，并在此框架的基础上进一步讨论了纤毛连接的意义和意义。
Once obscure, the cilium has come into the spotlight during the past decade. It is now clear that aside from generating locomotion by motile cilia, both motile and immotile cilia serve as signaling platforms for the cell. Through both motility and sensory functions, cilia play critical roles in development, homeostasis, and disease. To date, the cilium proteome contains more than 1,000 different proteins, and human genetics is identifying new ciliopathy genes at an increasing pace. Although assigning a function to immotile cilia was a challenge not so long ago, the myriad of signaling pathways, proteins, and biological processes associated with the cilium have now created a new obstacle: how to distill all these interactions into specific themes and mechanisms that may explain how the organelle serves to maintain organism homeostasis. Here, we review the basics of cilia biology, novel functions associated with cilia, and recent advances in cilia genetics, and on the basis of this framework, we further discuss the meaning and significance of ciliary connections.
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影响因子：
64.5
作者：
Chaki M;Airik R;Ghosh AK;Giles RH;Chen R;Slaats GG;Wang H;Hurd TW;Zhou W;Cluckey A;Gee HY;Ramaswami G;Hong CJ;Hamilton BA;Cervenka I;Ganji RS;Bryja V;Arts HH;van Reeuwijk J;Oud MM;Letteboer SJ;Roepman R;Husson H;Ibraghimov-Beskrovnaya O;Yasunaga T;Walz G;Eley L;Sayer JA;Schermer B;Liebau MC;Benzing T;Le Corre S;Drummond I;Janssen S;Allen SJ;Natarajan S;O'Toole JF;Attanasio M;Saunier S;Antignac C;Koenekoop RK;Ren H;Lopez I;Nayir A;Stoetzel C;Dollfus H;Massoudi R;Gleeson JG;Andreoli SP;Doherty DG;Lindstrad A;Golzio C;Katsanis N;Pape L;Abboud EB;Al-Rajhi AA;Lewis RA;Omran H;Lee EY;Wang S;Sekiguchi JM;Saunders R;Johnson CA;Garner E;Vanselow K;Andersen JS;Shlomai J;Nurnberg G;Nurnberg P;Levy S;Smogorzewska A;Otto EA;Hildebrandt F
通讯作者：
Hildebrandt F
影响因子：
14.9
作者：
Cade L;Reyon D;Hwang WY;Tsai SQ;Patel S;Khayter C;Joung JK;Sander JD;Peterson RT;Yeh JR
通讯作者：
Yeh JR
影响因子：
64.8
作者：
Barr, MM;Sternberg, PW
通讯作者：
Sternberg, PW
影响因子：
1
作者：
Cohen, Meryl S.;Anderson, Robert H.;Weinberg, Paul M.
通讯作者：
Weinberg, Paul M.
影响因子：
4.6
作者：
Banizs, B;Pike, MM;Yoder, BK
通讯作者：
Yoder, BK