Cooling-Induced Carotid Artery Dilatation: An Experimental Study in Isolated Vessels
Cooling-Induced Carotid Artery Dilatation: An Experimental Study in Isolated Vessels
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冷却引起的颈动脉扩张：孤立血管的实验研究
DOI：
10.1161/hs0102.101545
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
O. Thulesius
中科院分区：
文献类型：
--
作者：
S. Mustafa;O. Thulesius
背景和目的-临床和实验研究似乎表明，低温可以改善中风患者的预后，减少实验性脑损伤。目前的解释是，冷却通过减少大脑代谢而具有神经保护作用。本研究的目的是检验低温诱导动脉血管舒张从而增加脑血流量的假设。方法：我们记录了器官浴中家兔颈动脉条在逐步冷却过程中的等长张力.在基础张力下，在去甲肾上腺素预收缩的血管中，以及在电场刺激后，测试冷却反应。结果-从37°C到4°C的逐步冷却诱导可再现的分级弛豫，与温度成反比。在基础张力和预收缩血管中可引起反应。冷却降低了对去甲肾上腺素和氯化钾的收缩反应。在20°C下冷却降低了对电场刺激的收缩反应，而在10°C下这些反应完全消失。冷却诱导的血管舒张不依赖于内皮机制。结论：冷却颈动脉制剂可诱导可逆的分级血管舒张，并降低或消除血管收缩神经递质的作用。局部低温的效果可以增加脑血流量，并可能构成一个积极的治疗模式，在中风患者。
Background and Purpose— Clinical and experimental studies seem to indicate that hypothermia may improve outcome in stroke victims and reduce experimental brain injury. The current interpretation is that cooling has a neuroprotective effect by reducing brain metabolism. The objective of our study was to test the hypothesis that hypothermia induces arterial vasodilatation and thereby increases cerebral blood flow. Methods— We recorded isometric tension in rabbit carotid artery strips in organ baths during stepwise cooling. The cooling responses were tested at basal tone, in noradrenaline-precontracted vessels, and after electric field stimulation. Results— Stepwise cooling from 37°C to 4°C induced reproducible graded relaxation, inversely proportional to temperature. The responses could be elicited at basal tone and in precontracted vessels. Cooling decreased the contractile responses to norepinephrine and potassium chloride. Cooling at 20°C decreased the contractile responses to electric field stimulation, while at 10°C these were totally abolished. Cooling-induced vasodilatation is not dependent on an endothelial mechanism. Conclusions— Cooling of carotid artery preparations induced a reversible graded vasodilatation and decreased or abolished the effect of vasocontractile neurotransmitters. The effect of local hypothermia could increase cerebral blood flow and may constitute a positive therapeutic modality in stroke patients.
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影响因子：
8.3
作者：
Maier, CM;Ahern, KV;Steinberg, GK
通讯作者：
Steinberg, GK
选择性脑冷却会增加大鼠皮质脑血流量。
DOI：
10.1152/ajpheart.1993.265.3.h824
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Kuluz,JW;Prado,R;Chang,J;Ginsberg,MD;Schleien,CL;Busto,R
通讯作者：
Busto,R
影响因子：
158.5
作者：
Clifton, GL;Miller, ER;Schwartz, M
通讯作者：
Schwartz, M
缺血内低温对可逆局灶性缺血模型脑损伤的影响。
影响因子：
4.8
作者：
Goto,Y;Kassell,NF;Hiramatsu,K;Soleau,SW;Lee,KS
通讯作者：
Lee,KS