Real-time size modulation and synchronization of a microfluidic dropmaker with pulsed surface acoustic waves (SAW).
Real-time size modulation and synchronization of a microfluidic dropmaker with pulsed surface acoustic waves (SAW).
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DOI：
10.1038/s41598-018-22529-w
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发表时间：
2018-03-14
影响因子：
4.6
通讯作者：
Franke T
中科院分区：
文献类型：
--
作者：
Schmid L;Franke T
我们表明，一个微流控流聚焦液滴制造器可以同步到表面声波（SAW）由外部电信号触发。以这种方式，液滴速率和体积可以在真实的时间内在宽范围的值上被控制。使用SAW，可以通过声学地强制液滴夹断并由此减小体积来增加没有SAW的常规操作的油包水液滴制造器的液滴形成速率。产生长度l = 10 w的大液滴的方形横截面（w = h = 30 µm，宽度w和高度h）的液滴发生器可以被触发产生l ~ 2 w的液滴，接近几何极限l = w而不改变流速。与通过改变流速来调节液滴大小的设备不同，声学液滴制造器具有非常短的瞬变，允许调节每个液滴的大小。这使我们能够生产具有确定尺寸分布的定制乳液，如本文所示，不仅用于单分散乳液，而且用于具有交替尺寸的液滴的二元乳液。此外，我们表明，我们的设备的鲁棒性和单分散性增强相比，纯粹的流量驱动的液滴制造商在没有声同步。
We show that a microfluidic flow focusing drop maker can be synchronized to a surface acoustic waves (SAW) triggered by an external electric signal. In this way droplet rate and volume can be controlled over a wide range of values in real time. Using SAW, the drop formation rate of a regularly operating water in oil drop maker without SAW can be increased by acoustically enforcing the drop pinch-off and thereby reducing the volume. Drop makers of square cross-sections (w = h = 30 µm, with width w and height h) that produce large drops of length l = 10 w can be triggered to produce drops as short as l ~ 2w, approaching the geometical limit l = w without changing the flow rates. Unlike devices that adjust drop size by changing the flow rates the acoustic dropmaker has very short transients allowing to adjust the size of every single drop. This allows us to produce custom made emulsions with a defined size distribution as demonstrated here not only for a monodisperse emulsion but also for binary emulsions with drops of alternating size. Moreover, we show that the robustness and monodispersity of our devices is enhanced compared to purely flow driven drop makers in the absence of acoustic synchronization.
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影响因子：
24.2
作者：
Shah, Rhutesh K.;Shum, Ho Cheung;Weitz, David A.
通讯作者：
Weitz, David A.
DOI：
10.1038/nrm4041
发表时间：
2015-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Duncombe TA;Tentori AM;Herr AE
通讯作者：
Herr AE
影响因子：
3.7
作者：
De Menech, M.;Garstecki, P.;Stone, H. A.
通讯作者：
Stone, H. A.
影响因子：
4
作者：
Abate, Adam R.;Romanowsky, Mark B.;Weitz, David A.
通讯作者：
Weitz, David A.
影响因子：
6.1
作者：
Schmid, Lothar;Franke, Thomas
通讯作者：
Franke, Thomas